Key role of CD4+ T cells in determining CD8 function during CAR-T cell manufacture.
作者信息
Melenhorst J Joseph, Oliveira Beatriz C
机构信息
Cell Therapy & ImmunoEngineering Program, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA
University of Pennsylvania, Philadelphia, Pennsylvania, USA.
出版信息
J Immunother Cancer. 2024 Mar 13;12(3):e008723. doi: 10.1136/jitc-2023-008723.
Abstract
摘要
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J Immunother Cancer. 2023 Nov 20;11(11):e007803. doi: 10.1136/jitc-2023-007803.
2
Decade-long leukaemia remissions with persistence of CD4 CAR T cells.长达十年的白血病缓解期与 CD4 CAR T 细胞的持续存在。
Nature. 2022 Feb;602(7897):503-509. doi: 10.1038/s41586-021-04390-6. Epub 2022 Feb 2.
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IL15 Enhances CAR-T Cell Antitumor Activity by Reducing mTORC1 Activity and Preserving Their Stem Cell Memory Phenotype.白细胞介素 15 通过降低 mTORC1 活性和维持其干细胞记忆表型增强 CAR-T 细胞的抗肿瘤活性。
Cancer Immunol Res. 2019 May;7(5):759-772. doi: 10.1158/2326-6066.CIR-18-0466. Epub 2019 Mar 19.
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Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia.慢性淋巴细胞白血病中 CD19 嵌合抗原受体 (CAR) T 细胞治疗应答和耐药的决定因素。
Nat Med. 2018 May;24(5):563-571. doi: 10.1038/s41591-018-0010-1. Epub 2018 Apr 30.
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