The Affiliated Hospital of Putian University, Putian University, No.999 Dongzhen East Road, Licheng District, Putian, Fujian, China.
Comprehensive Technology Service Center of Quanzhou Customs, Inspection and Quarantine Bureau Building, South Section of Citong East Road, Quanzhou, Fujian, China.
BMC Infect Dis. 2024 Mar 14;24(1):315. doi: 10.1186/s12879-024-09180-9.
This study aims to explore the infection and age distribution of Ureaplasma urealyticum (UU), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Herpes simplex virus type II (HSV II) among the outpatients of Reproductive Medicine Center in Putian, Fujian Province to provide a clinical basis for the early diagnosis and treatment of various reproductive tract diseases and infertility in this region.
A total of 1736 samples of secretions and exfoliated cervical cells were collected from the outpatients of the Reproductive Medicine Center of the Affiliated Hospital of Putian University from December 2021 to April 2023. The infections of UU, CT, NG and HSVII were detected by real-time fluorescence polymerase chain reaction (PCR), and the infection statuses of the patients with different genders, ages and diagnoses were analysed.
Among the 1736 patients, 611 were male and 1125 were female. The male patients had higher UU infection rate but lower HSV II infection rate than the female patients. No significant difference in CT and NG infection rates was observed between the genders. The CT infection rate gradually decreased with the increase in the age. The difference in UU, NG and HSV II infection rates among the different age groups was not statistically significant. For UU infection, the male infertile patients had the highest rate of 37.72% (172/456). Meanwhile, the differences in CT, NG and HSV II infection rates among the different diagnosis groups were not statistically significant. Among the male and female infertile patients, the CT infection rate was the highest in the 21-25 years of age group at 11.11% (2/18) and 9.47% (9/95), respectively. No statistically significant difference in UU, CT, NG and HSV II infection rates was observed among the different age groups of patients diagnosed in relation to the family planning guidance and between the male and female patients with other diagnoses results.
This study showed that UU was the most frequently identified pathogen in infertile men in Putian, Fujian Province. The CT infection rate was the highest in people under 20 years old, and the infection showed a tendency toward young individuals. Therefore, the publicity of sexual health knowledge must be strengthened, and the prevention and treatment of venereal diseases among young and middle-aged people must be improved. Moreover, the pathogen infection is related to infertility to a certain extent, which is conducive to clinical diagnosis and treatment.
本研究旨在探讨福建省莆田市生殖医学中心门诊患者中解脲支原体（UU）、沙眼衣原体（CT）、淋病奈瑟菌（NG）和单纯疱疹病毒 II 型（HSV II）的感染和年龄分布，为该地区各种生殖道疾病和不孕不育的早期诊断和治疗提供临床依据。
2021 年 12 月至 2023 年 4 月，收集莆田学院附属医院生殖医学中心门诊患者 1736 例分泌物和宫颈脱落细胞标本，采用实时荧光聚合酶链反应（PCR）检测 UU、CT、NG 和 HSV II 的感染情况，分析不同性别、年龄和诊断患者的感染状况。
1736 例患者中，男性 611 例，女性 1125 例。男性 UU 感染率高于女性，HSV II 感染率低于女性。性别间 CT 和 NG 感染率无显著差异。CT 感染率随年龄增长逐渐降低。不同年龄组 UU、NG 和 HSV II 感染率差异无统计学意义。UU 感染方面，男性不育患者感染率最高，为 37.72%（172/456）。同时，不同诊断组 CT、NG 和 HSV II 感染率差异无统计学意义。在男性和女性不育患者中，21-25 岁年龄组 CT 感染率最高，分别为 11.11%（2/18）和 9.47%（9/95）。不同年龄组计划生育指导和其他诊断结果的男性和女性患者间 UU、CT、NG 和 HSV II 感染率差异无统计学意义。
本研究表明，UU 是福建省莆田市不育男性中最常见的病原体。CT 感染率在 20 岁以下人群中最高，感染呈年轻化趋势。因此，必须加强性健康知识的宣传，提高中青年人的性病防治水平。此外，病原体感染与不孕不育有一定的关系，有利于临床诊断和治疗。
