Wang Ziran, Xia Mingqi, Chen Yu, Yang Zhuo, Yi Jie, Kong Lingjun, Zhang Han, Luo Guoju, Li Rui, Dou Yaling
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Department of Education, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Eur J Clin Microbiol Infect Dis. 2023 Dec;42(12):1425-1437. doi: 10.1007/s10096-023-04678-7. Epub 2023 Oct 16.
Ureaplasma species are common pathogens of the urogenital tract and can cause a range of diseases. Unfortunately, there is still a scarcity of large-scale and cross-sectional studies on the prevalence of Ureaplasma species in China to clarify their epidemic patterns.
This study retrospectively analyzed the data of 18667 patients who visited Peking Union Medical College Hospital for showing various symptoms of (suspected) Ureaplasma species infection during the period 2013-2022. The overall prevalence of Ureaplasma species was calculated, and subgroup analyses were conducted in view of gender, age, specimen types, and diagnosis in every year within the period studied. Furthermore, previous literature that reported on the prevalence of Ureaplasma species in various regions of China was searched and summarized.
The overall positive rate of Ureaplasma species in this study reached 42.1% (7861/18667). Specifically, the prevalence of Ureaplasma species was significantly higher in female patients, while the highest detection rate was found in the 21-50 age group. From 2013 to 2022, there were no significant differences in positive rates of Ureaplasma species among years. However, the detection rate of Ureaplasma species was decreased in COVID-19 period (2020-2022) compared to pre-COVID-19 period (2017-2019). In view of the distribution of patients, outpatients predominated, but the detection rate was lower than inpatients. Urine was the most common specimen type, while cervical swabs had the highest detection rate of Ureaplasma species. When grouped by diagnosis, the highest positive rate of Ureaplasma species was seen in patients with adverse pregnancy outcomes and the lowest rate in patients with prostate disease. The previous literature, although heterogeneous, collectively suggested a high prevalence of Ureaplasma species in China.
Our study has shown that Ureaplasma species have reached a significant prevalence in China and demands adequate attention.
解脲脲原体属是泌尿生殖道常见病原体，可引发一系列疾病。遗憾的是，目前中国仍缺乏大规模横断面研究来阐明解脲脲原体属的流行模式。
本研究回顾性分析了2013年至2022年期间因出现（疑似）解脲脲原体属感染的各种症状而就诊于北京协和医院的18667例患者的数据。计算了解脲脲原体属的总体患病率，并针对研究期间各年份的性别、年龄、标本类型和诊断情况进行了亚组分析。此外，检索并总结了此前报道中国不同地区解脲脲原体属患病率的文献。
本研究中解脲脲原体属的总体阳性率达42.1%（7861/18667）。具体而言，女性患者中解脲脲原体属的患病率显著更高，而在21至50岁年龄组中检测率最高。2013年至2022年期间，各年份解脲脲原体属的阳性率无显著差异。然而，与新冠疫情前时期（2017 - 2019年）相比，新冠疫情期间（2020 - 2022年）解脲脲原体属的检测率有所下降。就患者分布而言，门诊患者占主导，但检测率低于住院患者。尿液是最常见的标本类型，而宫颈拭子的解脲脲原体属检测率最高。按诊断分组时，不良妊娠结局患者的解脲脲原体属阳性率最高，前列腺疾病患者的阳性率最低。此前的文献尽管存在异质性，但总体表明中国解脲脲原体属的患病率较高。
我们的研究表明，解脲脲原体属在中国已达到相当高的患病率，需要给予充分关注。
