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RE: Exploring the cross-cancer effect of circulating proteins and discovering potential intervention targets for 13 site-specific cancers.

作者信息

Yarmolinsky James, Tzoulaki Ioanna, Gunter Marc J, Travis Ruth C, Davey Smith George, Smith-Byrne Karl

机构信息

Cancer Epidemiology and Prevention Research Unit, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.

Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.

出版信息

J Natl Cancer Inst. 2024 May 8;116(5):764-765. doi: 10.1093/jnci/djae064.

DOI:10.1093/jnci/djae064
PMID:38486358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11077299/
Abstract
摘要

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Plasma proteomic associations with genetics and health in the UK Biobank.英国生物库中血浆蛋白质组与遗传学和健康的关联。
Nature. 2023 Oct;622(7982):329-338. doi: 10.1038/s41586-023-06592-6. Epub 2023 Oct 4.
3
Mendelian randomization.孟德尔随机化
Nat Rev Methods Primers. 2022 Feb 10;2. doi: 10.1038/s43586-021-00092-5.
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Mendelian randomization for studying the effects of perturbing drug targets.用于研究干扰药物靶点效应的孟德尔随机化方法。
Wellcome Open Res. 2021 Feb 10;6:16. doi: 10.12688/wellcomeopenres.16544.2. eCollection 2021.
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Evaluating the potential role of pleiotropy in Mendelian randomization studies.评估多效性在孟德尔随机化研究中的潜在作用。
Hum Mol Genet. 2018 Aug 1;27(R2):R195-R208. doi: 10.1093/hmg/ddy163.
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Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption.基于零模态异质性假设的汇总数据孟德尔随机化的稳健推断。
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