Niazi Elaha, Dumanski Sandra M
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Libin Cardiovascular Institute, Calgary, Alberta, Canada.
CJC Open. 2023 Sep 15;6(2Part B):142-152. doi: 10.1016/j.cjco.2023.09.008. eCollection 2024 Feb.
Cardiovascular (CV) disease is the leading cause of death in women, and it may manifest differently than in men, in part related to sex-specific CV risk factors. In females, assisted reproductive technologies (ARTs) are commonly used to treat infertility, and they utilize controlled ovarian stimulation involving the administration of exogenous sex hormones. ARTs, and especially controlled ovarian stimulation, have been associated with an increased pregnancy and short-term CV risk, although the long-term CV implications of these treatments in individuals treated with ARTs and their offspring remain unclear. This review endeavors to provide a comprehensive examination of what is known about the relationship between ART and CV outcomes for females treated with ARTs, as well as their offspring, and recommendations for future research. Novel insights into female-specific CV risk factors are critical to reduce the disproportionate burden of CV disease in Canadian women. ART has revolutionized reproductive medicine, offering hope to millions of individuals with infertility worldwide, and a further understanding of the CV implications of this important sex-specific CV risk factor is warranted urgently.
心血管（CV）疾病是女性死亡的主要原因，其表现可能与男性不同，部分原因与特定性别的心血管危险因素有关。在女性中，辅助生殖技术（ARTs）常用于治疗不孕症，这些技术采用控制性卵巢刺激，包括给予外源性性激素。ARTs，尤其是控制性卵巢刺激，与妊娠增加和短期心血管风险相关，尽管这些治疗对接受ARTs治疗的个体及其后代的长期心血管影响仍不清楚。本综述旨在全面探讨关于接受ARTs治疗的女性及其后代的ARTs与心血管结局之间关系的已知情况，并提出未来研究的建议。对女性特异性心血管危险因素的新见解对于减轻加拿大女性心血管疾病的不均衡负担至关重要。ARTs彻底改变了生殖医学，为全球数百万不孕症患者带来了希望，因此迫切需要进一步了解这一重要的性别特异性心血管危险因素对心血管的影响。
