Lodi Matteo B, Makridis Antonios, Kazeli Konstantina, Samaras Theodoros, Angelakeris Makis, Mazzarella Giuseppe, Fanti Alessandro
Department of Electrical and Electronic EngineeringUniversity of Cagliari 09123 Cagliari Italy.
Nanostructure Characterization: Technology and ApplicationsCIRI-AUTH 57001 Thessaloniki Greece.
IEEE Open J Eng Med Biol. 2023 Aug 14;5:88-98. doi: 10.1109/OJEMB.2023.3304812. eCollection 2024.
Deep-seated tumors (DST) can be treated using thermoseeds exposed to a radiofrequency magnetic field for performing local interstitial hyperthermia treatment (HT). Several research efforts were oriented to the manufacturing of novel biocompatible magnetic nanostructured thermo-seeds, called magnetic scaffolds (MagS). Several iron-doped bioceramics or magnetic polymers in various formulations are available. However, the crucial evaluation of their heating potential has been carried out with significantly different, lab specific, variable experimental conditions and protocols often ignoring the several error sources and inaccuracies estimation. This work comments and provides a perspective analysis of an experimental protocol for the estimation methodology of the specific absorption rate (SAR) of MagS for DST HT. Numerical multiphysics simultions have been performed to outline the theoretical framework. After the in silico analysis, an experimental case is considered and tested. From the simulations, we found that large overestimation in the SAR values can be found, due to the axial misplacement in the radiofrequency coil, while the radial misplacement has a lower impact on the estimated SAR value. The averaging of multiple temperature records is needed to reliably and effectively estimate the SAR of MagS for DST HT.
深部肿瘤（DST）可以通过将热籽暴露于射频磁场来进行局部间质热疗（HT）。多项研究致力于制造新型生物相容性磁性纳米结构热籽，即所谓的磁性支架（MagS）。有几种不同配方的铁掺杂生物陶瓷或磁性聚合物可供使用。然而，对其加热潜力的关键评估是在显著不同、特定实验室的可变实验条件和方案下进行的，这些条件和方案往往忽略了几个误差来源和不准确估计。 本文对用于DST HT的MagS比吸收率（SAR）估计方法的实验方案进行了评论并提供了前瞻性分析。进行了数值多物理场模拟以勾勒出理论框架。在计算机模拟分析之后，考虑并测试了一个实验案例。 从模拟中我们发现，由于射频线圈中的轴向错位，SAR值可能会被大幅高估，而径向错位对估计的SAR值影响较小。 需要对多个温度记录进行平均，以可靠且有效地估计用于DST HT的MagS的SAR。
