Rubia-Rodríguez Irene, Santana-Otero Antonio, Spassov Simo, Tombácz Etelka, Johansson Christer, De La Presa Patricia, Teran Francisco J, Del Puerto Morales María, Veintemillas-Verdaguer Sabino, Thanh Nguyen T K, Besenhard Maximilian O, Wilhelm Claire, Gazeau Florence, Harmer Quentin, Mayes Eric, Manshian Bella B, Soenen Stefaan J, Gu Yuanyu, Millán Ángel, Efthimiadou Eleni K, Gaudet Jeff, Goodwill Patrick, Mansfield James, Steinhoff Uwe, Wells James, Wiekhorst Frank, Ortega Daniel
IMDEA Nanoscience, Faraday 9, 28049 Madrid, Spain.
Geophysical Centre of the Royal Meteorological Institute, 1 rue du Centre Physique, 5670 Dourbes, Belgium.
Materials (Basel). 2021 Feb 3;14(4):706. doi: 10.3390/ma14040706.
The scientific community has made great efforts in advancing magnetic hyperthermia for the last two decades after going through a sizeable research lapse from its establishment. All the progress made in various topics ranging from nanoparticle synthesis to biocompatibilization and in vivo testing have been seeking to push the forefront towards some new clinical trials. As many, they did not go at the expected pace. Today, fruitful international cooperation and the wisdom gain after a careful analysis of the lessons learned from seminal clinical trials allow us to have a future with better guarantees for a more definitive takeoff of this genuine nanotherapy against cancer. Deliberately giving prominence to a number of critical aspects, this opinion review offers a blend of state-of-the-art hints and glimpses into the future of the therapy, considering the expected evolution of science and technology behind magnetic hyperthermia.
在经历了从创立到相当长一段时间的研究停滞之后，科学界在过去二十年里为推进磁热疗做出了巨大努力。从纳米颗粒合成到生物相容性以及体内测试等各个主题所取得的所有进展，都一直在努力将前沿推向一些新的临床试验。和许多情况一样，它们的进展并未达到预期速度。如今，富有成效的国际合作以及在对开创性临床试验的经验教训进行仔细分析后所获得的智慧，让我们对这种针对癌症的真正纳米疗法更有把握地迎来更确定的腾飞充满期待。本观点综述特意突出了一些关键方面，结合了磁热疗背后科学技术的预期发展，对该疗法的现状和未来进行了展望。
