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J Neural Transm (Vienna). 2024 Sep;131(9):999-1012. doi: 10.1007/s00702-024-02794-y. Epub 2024 Jun 14.

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Different depression: motivational anhedonia governs antidepressant efficacy in Huntington's disease.不同类型的抑郁症：动机性快感缺乏决定亨廷顿舞蹈症的抗抑郁药疗效。
Brain Commun. 2022 Nov 9;4(6):fcac278. doi: 10.1093/braincomms/fcac278. eCollection 2022.
2
Neuropsychiatric Burden in Huntington's Disease.亨廷顿舞蹈症的神经精神负担
Brain Sci. 2017 Jun 16;7(6):67. doi: 10.3390/brainsci7060067.
3
CARE guidelines for case reports: explanation and elaboration document.病例报告的CARE指南：解释与阐述文件。
J Clin Epidemiol. 2017 Sep;89:218-235. doi: 10.1016/j.jclinepi.2017.04.026. Epub 2017 May 18.
4
Deep rTMS for Neuropsychiatric Symptoms of Huntington's Disease: Case Report.深部重复经颅磁刺激治疗亨廷顿舞蹈病神经精神症状：病例报告
Brain Stimul. 2016 Nov-Dec;9(6):960-961. doi: 10.1016/j.brs.2016.09.002. Epub 2016 Sep 13.
5
Oxidative Stress and Huntington's Disease: The Good, The Bad, and The Ugly.氧化应激与亨廷顿舞蹈症：益处、危害与严峻之处
J Huntingtons Dis. 2016 Oct 1;5(3):217-237. doi: 10.3233/JHD-160205.
6
Neuropsychiatric symptoms are very common in premanifest and early stage Huntington's Disease.神经精神症状在亨廷顿舞蹈症的临床前和早期阶段非常常见。
Parkinsonism Relat Disord. 2016 Apr;25:58-64. doi: 10.1016/j.parkreldis.2016.02.008. Epub 2016 Feb 11.
7
Transcranial magnetic stimulation as a tool for understanding neurophysiology in Huntington's disease: a review.经颅磁刺激在亨廷顿病神经生理学研究中的应用：综述。
Neurosci Biobehav Rev. 2013 Sep;37(8):1420-33. doi: 10.1016/j.neubiorev.2013.05.009. Epub 2013 May 29.
8
Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.亨廷顿病的病理生理学：突触和受体功能的时变改变。
Neuroscience. 2011 Dec 15;198:252-73. doi: 10.1016/j.neuroscience.2011.08.052. Epub 2011 Aug 27.
9
Huntingtons Disease: The Value of Transcranial Meganetic Stimulation.亨廷顿病：经颅磁刺激的价值。
Curr Med Chem. 2010;17(23):2482-91. doi: 10.2174/092986710791556078.
10
Protein misfolding inside cells: the case of huntingtin and Huntington's disease.细胞内蛋白质错误折叠：亨廷顿蛋白与亨廷顿舞蹈症的案例
IUBMB Life. 2008 Nov;60(11):724-8. doi: 10.1002/iub.111.

重复经颅磁刺激治疗亨廷顿病患者的重度抑郁症，神经精神症状和运动症状均有改善：一例报告

Repetitive Transcranial Magnetic Stimulation for Major Depressive Disorder in Huntington Disease Patient with Improvement in Neuropsychiatric and Movement Symptoms: A Case Report.

作者信息

Rahn Cheyenne, Peterson Kris, Lamb Elizabeth

机构信息

College of Osteopathic Medicine, Pacific Northwest University, Yakima, WA, USA.

Touchstone TMS, Lakewood, WA, USA.

出版信息

Case Rep Neurol. 2024 Feb 14;16(1):79-84. doi: 10.1159/000537750. eCollection 2024 Jan-Dec.

DOI:10.1159/000537750
PMID:38487476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10939509/
Abstract

INTRODUCTION

Huntington disease (HD) is a progressive disorder characterized by significant neurodegeneration that results in severe neuropsychiatric symptoms and disordered movement. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive treatment that has been used in major depressive disorder (MDD) with great success.

CASE PRESENTATION

We present a case of a patient with newly diagnosed HD, persistent MDD with suicidal ideation, and generalized anxiety disorder who was treated with rTMS and had sustained significant improvement of her mood disorder with additional improvement of her movement disorder.

CONCLUSION

This result brings into question the use of rTMS to treat MDD and chorea in patients with HD, especially early in its course.

摘要

引言

亨廷顿舞蹈症（HD）是一种进行性疾病，其特征是严重的神经退行性变，导致严重的神经精神症状和运动障碍。重复经颅磁刺激（rTMS）是一种非侵入性治疗方法，已在重度抑郁症（MDD）的治疗中取得了巨大成功。

病例报告

我们报告一例新诊断为HD的患者，伴有持续性MDD和自杀意念以及广泛性焦虑症，该患者接受了rTMS治疗，其情绪障碍得到持续显著改善，运动障碍也有所改善。

结论

这一结果使人质疑rTMS在HD患者中治疗MDD和舞蹈症的应用，尤其是在病程早期。