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药物难治性室性心动过速合并左心室血栓患者的外科心室重建及术中冷冻消融:病例报告

Surgical ventricular reconstruction and intraoperative cryoablation in a patient with drug-refractory ventricular tachycardia and left ventricular thrombus: a case report.

作者信息

Lopez Maryuri Delgado, Vogler Julia, Aboud Anas, Heeger Christian-Hendrik, Tilz Roland Richard

机构信息

Department of Rhythmology, University Heart Center Lübeck, University Hospital Schleswig-Holstein (UKSH), Campus Lübeck, Ratzeburger Allee 160, Lübeck 23538, Germany.

Department of Cardiac and Thoracic Vascular Surgery, University of Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.

出版信息

Eur Heart J Case Rep. 2024 Mar 4;8(3):ytae113. doi: 10.1093/ehjcr/ytae113. eCollection 2024 Mar.

Abstract

BACKGROUND

Despite modern techniques for ablation of ventricular tachycardia (VT), the procedure faces challenges such as deep intramural substrates or inaccessibility of the pericardial space. We aim to present a case of successful surgical treatment of a patient with drug-refractory VT, an apical aneurysm, large left ventricular (LV) thrombus, and recurrent implantable cardioverter defibrillator (ICD) shocks following failed epicardial catheter ablation.

CASE SUMMARY

A 67-year-old male with a history of ischaemic cardiomyopathy was brought to the emergency room after a syncope because of VT. The VT was terminated by an external cardioversion prior to admission. The ICD interrogation showed an episode of sustained monomorphic VT with eight appropriate but mostly ineffective ICD shocks. An echocardiogram revealed an apical aneurysm with a thrombus. Anticoagulation and antiarrhythmic drug therapy were initiated. Days later, the patient suffered recurrent episodes of sustained VTs, refractory to pharmacological therapy, and epicardial ablation; therefore, following aneurysmectomy and thrombus removal, a reconstruction of the LV and surgical endocardial cryoablation were performed. In addition, ICD extraction was done due to recurrent bacteraemia with . A subcutaneous ICD was later implanted. After surgery, the patient remained free of any VT episodes during 44 months of follow-up.

CONCLUSION

Combined surgical ventricular reconstruction and intraoperative cryoablation may be considered as an alternative, highly effective therapy in patients with drug-refractory VTs in the setting of a LV thrombus.

摘要

背景

尽管有用于消融室性心动过速(VT)的现代技术,但该手术仍面临挑战,如深层壁内基质或心包腔难以触及。我们旨在介绍一例成功手术治疗药物难治性室性心动过速、心尖部动脉瘤、巨大左心室(LV)血栓以及心外膜导管消融失败后反复植入式心律转复除颤器(ICD)电击的患者。

病例摘要

一名有缺血性心肌病病史的67岁男性因室性心动过速晕厥后被送往急诊室。入院前室性心动过速通过体外复律终止。ICD 询问显示有一次持续单形性室性心动过速发作,ICD 有八次适当但大多无效的电击。超声心动图显示心尖部动脉瘤伴血栓形成。开始抗凝和抗心律失常药物治疗。数天后,患者反复出现持续室性心动过速发作,对药物治疗和心外膜消融均无效;因此,在进行动脉瘤切除术和血栓清除术后,进行了左心室重建和外科心内膜冷冻消融。此外,由于反复出现菌血症,进行了 ICD 拔除。后来植入了皮下 ICD。术后,患者在44个月的随访期间未再出现任何室性心动过速发作。

结论

对于左心室血栓情况下药物难治性室性心动过速患者,联合手术性心室重建和术中冷冻消融可被视为一种替代的、高效的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3926/10939119/69608d41fbdf/ytae113il2.jpg

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