Yang Yang, Yuan QuPing, Tang Weijian, Ma Ya, Duan JingYan, Yang GuoNing, Fang Yuan
Otorhinolaryngology Head and Neck Surgery, Baoshan People's Hospital, Baoshan, Yunnan, China.
Puer People's Hospital, Department of Critical Medicine, PuEr, Yunnan, China.
Front Oncol. 2024 Feb 29;14:1346413. doi: 10.3389/fonc.2024.1346413. eCollection 2024.
Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the nasopharyngeal epithelial cells. Common treatment methods for NPC include radiotherapy, chemotherapy, and surgical intervention. Despite these approaches, the prognosis for NPC remains poor due to treatment resistance and recurrence. Hence, there is a crucial need for more comprehensive research into the mechanisms underlying treatment resistance in NPC. Long non coding RNAs (LncRNAs) are elongated RNA molecules that do not encode proteins. They paly significant roles in various biological processes within tumors, such as chemotherapy resistance, radiation resistance, and tumor recurrence. Recent studies have increasingly unveiled the mechanisms through which LncRNAs contribute to treatment resistance in NPC. Consequently, LncRNAs hold promise as potential biomarkers and therapeutic targets for diagnosing NPC. This review provides an overview of the role of LncRNAs in NPC treatment resistance and explores their potential as therapeutic targets for managing NPC.
鼻咽癌（NPC）是一种起源于鼻咽上皮细胞的恶性肿瘤。鼻咽癌的常见治疗方法包括放射治疗、化学治疗和手术干预。尽管有这些治疗方法，但由于治疗抵抗和复发，鼻咽癌的预后仍然很差。因此，迫切需要对鼻咽癌治疗抵抗的潜在机制进行更全面的研究。长链非编码RNA（LncRNAs）是不编码蛋白质的长链RNA分子。它们在肿瘤内的各种生物学过程中发挥重要作用，如化疗抵抗、放射抵抗和肿瘤复发。最近的研究越来越多地揭示了LncRNAs导致鼻咽癌治疗抵抗的机制。因此，LncRNAs有望成为诊断鼻咽癌的潜在生物标志物和治疗靶点。本综述概述了LncRNAs在鼻咽癌治疗抵抗中的作用，并探讨了它们作为治疗鼻咽癌靶点的潜力。
