He Rongzhang, Hu Zheng, Wang Qingmei, Luo Weihao, Li Jia, Duan Lili, Zhu Yuan-Shan, Luo Di-Xian
Translational Medicine Institute, National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis Technology, Collaborative Research Center for Post-doctoral Mobile Stations of Central South University, Affiliated the First People's Hospital of Chenzhou of University of South China, Chenzhou 432000, P.R. China.
Department of Clinical Pharmacology, Xiangya Hospital and Institute of Clinical Pharmacology, Central South University and Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan 410078, P.R. China.
Oncotarget. 2017 Feb 28;8(9):16075-16083. doi: 10.18632/oncotarget.14211.
Recent development of cutting edge research found that long noncoding RNAs (lncRNAs) plays important roles in carcinogenesis and progression. In Southeast Asia and North Africa, nasopharyngeal carcinoma (NPC) is the most common aggressive squamous cell carcinoma. Nasopharyngeal carcinoma is most frequently occurring in males. However, nasopharyngeal carcinoma is caused by a combination of several factors as viral, environmental factors, and heredity. Till now, the potential pathway or mechanism of NPC is not well known. In our present review, we strongly emphasized on long noncoding RNAs (lncRNAs) and its significant role in nasopharyngeal carcinoma. It has been showed that lncRNAs regulate the development and progression of different types of cancers, including NPC. In addition, it has been found that chromatin organization, transcriptional and post-transcriptional events are regulated by lncRNAs. Our present review summarizes the roles of lncRNAs in nasopharyngeal carcinoma and provides an overview of the feasibility of lncRNAs as diagnosis, prognosis and potential treatment for NPC patients.
前沿研究的最新进展发现，长链非编码RNA（lncRNAs）在肿瘤发生和发展中发挥着重要作用。在东南亚和北非，鼻咽癌（NPC）是最常见的侵袭性鳞状细胞癌。鼻咽癌在男性中最为常见。然而，鼻咽癌是由多种因素共同引起的，如病毒、环境因素和遗传因素。到目前为止，鼻咽癌的潜在途径或机制尚不清楚。在我们目前的综述中，我们着重强调了长链非编码RNA（lncRNAs）及其在鼻咽癌中的重要作用。研究表明，lncRNAs调节包括鼻咽癌在内的不同类型癌症的发生和发展。此外，还发现lncRNAs可调控染色质组织、转录和转录后事件。我们目前的综述总结了lncRNAs在鼻咽癌中的作用，并概述了lncRNAs作为鼻咽癌患者诊断、预后和潜在治疗手段的可行性。
