Liu Cui, Zheng Dan, Pu Xuan, Li Sijun
Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Front Oncol. 2024 Feb 28;14:1327933. doi: 10.3389/fonc.2024.1327933. eCollection 2024.
Histones have a vital function as components of nucleosomes, which serve as the fundamental building blocks of chromatin. Histone deacetylases (HDACs), which target histones, suppress gene transcription by compacting chromatin. This implies that HDACs have a strong connection to the suppression of gene transcription. Histone deacetylase 7 (HDAC7), a member of the histone deacetylase family, may participate in multiple cellular pathophysiological processes and activate relevant signaling pathways to facilitate the progression of different tumors by exerting deacetylation. In recent years, HDAC7 has been increasingly studied in the pathogenesis of tumors. Studies that are pertinent have indicated that it has a significant impact on the growth and metastasis of tumors, the formation of the vascular microenvironment, and the emergence of resistance to drugs. Therefore, HDAC7 could potentially function as a potent predictor for tumor prognosis and a promising target for mitigating drug resistance in tumors. This review primarily concentrates on elucidating the structure and function of HDAC7, its involvement in the development of various tumors, and its interplay with relevant signaling pathways. Meanwhile, we briefly discuss the research direction and prospect of HDAC7.
组蛋白作为核小体的组成部分具有至关重要的功能，核小体是染色质的基本构建单元。靶向组蛋白的组蛋白去乙酰化酶（HDACs）通过压缩染色质来抑制基因转录。这意味着HDACs与基因转录抑制有着紧密的联系。组蛋白去乙酰化酶7（HDAC7）是组蛋白去乙酰化酶家族的一员，可能参与多种细胞病理生理过程，并通过发挥去乙酰化作用激活相关信号通路，以促进不同肿瘤的进展。近年来，HDAC7在肿瘤发病机制方面受到越来越多的研究。相关研究表明，它对肿瘤的生长和转移、血管微环境的形成以及耐药性的出现具有重大影响。因此，HDAC7有可能作为肿瘤预后的有力预测指标以及缓解肿瘤耐药性的有前景的靶点。本综述主要集中于阐明HDAC7的结构和功能、其在各种肿瘤发生发展中的作用以及与相关信号通路的相互作用。同时，我们简要讨论HDAC7的研究方向和前景。
