Baran R, Dupré A, Sayag J, Letessier S, Robins P, Bureau H
Ann Dermatol Venereol. 1979 Mar;106(3):227-33.
Five cases of Bowen disease of the nail apparatus were studied and the 20 cases published to date reviewed. The lesion was characterized by either periungual redness with scaling and erosions, whitish cuticle, hyperkeratotic or papilomatous process, fissure or crusted ulcer in the lateral nail fold or the nail bed with eventual partial or total destruction of the nail plate and sometimes soreness on the pressure. The key of the diagnosis is the histological picture, identical with that of Bowen diseases of other skin areas. Among the 25 cases, Bowen disease was found mainly in males (20 out of 25 patients) on the left fingers (17 out of 25 finger lesions) with particular involvement of the 1st, 2nd, 3rd finger nail. Hallux was concerned twice. The clinical picture can be protean and mimic verrucae, onychomycosis, paronychia, eczema, pyogenic granuloma, verrucous tuberculosis, subungual exostosis, glomus tumor, dermatitis vegetans, amelanotic malignant melanoma, kerato-acanthoma and of course squamous cell carcinoma. Treatment of choice is complete removal of the tumor by plastic surgery otherwise microscopically controlled excision following chemical fixation (Mohs) or fresh tissue technique.
对5例甲器鲍恩病进行了研究，并对迄今为止已发表的20例病例进行了回顾。病变的特征为甲周发红伴脱屑和糜烂、白色角质层、角化过度或乳头瘤样病变、甲皱襞或甲床的裂隙或结痂溃疡，最终甲板部分或全部破坏，有时按压时有压痛。诊断的关键是组织学表现，与其他皮肤部位的鲍恩病相同。在这25例病例中，鲍恩病主要见于男性（25例患者中有20例），累及左手手指（25处手指病变中有17处），尤以第1、2、3指指甲受累为主。拇趾受累2次。临床表现多样，可模仿疣、甲癣、甲沟炎、湿疹、化脓性肉芽肿、疣状结核、甲下外生骨疣、血管球瘤、增殖性皮炎、无色素性恶性黑色素瘤、角化棘皮瘤，当然还有鳞状细胞癌。首选治疗方法是通过整形手术完全切除肿瘤，否则采用化学固定后显微镜控制切除（莫氏手术）或新鲜组织技术。
