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通过细胞外囊泡，对乙酰氨基酚对乙醇诱导的胃损伤的保护作用。

Protective effect of against ethanol-induced gastric injury via extracellular vesicles.

机构信息

School of Life Science and Engineering, Foshan University, Foshan, China.

Sanya Institute, Hainan Academy of Agricultural Sciences (Hainan Experimental Animal Research Center), Sanya, China.

出版信息

Microbiol Spectr. 2024 Apr 2;12(4):e0389423. doi: 10.1128/spectrum.03894-23. Epub 2024 Mar 15.

DOI:10.1128/spectrum.03894-23
PMID:38488394
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10986489/
Abstract

Recently, has been shown to have gastric protective functions, and the mechanisms by which modulates gastric function are still being investigated. Herein, we investigated how (Efm) and -derived extracellular vesicles (EVs) (EfmEVs) exert protective effect against ethanol-induced gastric injury by investigating the effect of EfmEVs on gastric mucosal ulcer scoring, histological lesion, mucosal glycoprotein production, acidity, anti-oxidative function, and inflammatory responses in rat. Pretreatment with Efm showed significant reduction of ethanol-induced gastric injury, as evidenced by the lowering of ulcer index, histological lesion, gastric pH, and inflammatory responses and the enhancement of mucosal glycoprotein production and anti-oxidative function. Further functional studies on three bioactive components [inactivated Efm, EfmEVs (EVs), and EV-free supernatants] of the bacterial culture showed that EVs are mostly responsible for the gastroprotective effect. Moreover, EV secretion is beneficial for the gastroprotective effect of Efm. Hence, EVs mediated the protective effect of Efm against ethanol-induced gastric injury by lowering inflammatory responses and enhancing anti-oxidative function and may be a potent anti-inflammatory and anti-oxidative strategy to alleviate hyperinflammatory gastrointestinal tract conditions.IMPORTANCEThis study indicated that provided a protective effect against rat gastric injury, which involved improvement of the mucosal glycoprotein production, anti-oxidative function, and inflammatory responses. Furthermore, we confirmed that three bioactive components (inactivated Efm, extracellular vesicles, and EV-free supernatants) of culture also contributed to the gastroprotective effect. Importantly, -derived EVs showed an effective impact for the gastroprotective effect.

摘要

最近，[成分名称]已被证明具有胃保护功能，而调节胃功能的机制仍在研究中。在此，我们通过研究[成分名称]衍生的细胞外囊泡（EVs）（EfmEVs）对乙醇诱导的胃损伤的保护作用，来研究其对胃黏膜溃疡评分、组织学损伤、黏膜糖蛋白产生、酸度、抗氧化功能和炎症反应的影响。结果表明，[成分名称]预处理可显著减轻乙醇诱导的胃损伤，表现为降低溃疡指数、组织学损伤、胃 pH 值和炎症反应，增强黏膜糖蛋白产生和抗氧化功能。进一步对细菌培养的三种生物活性成分[失活的[成分名称]、EVs（EVs）和 EV 无细胞上清液]进行功能研究表明，EVs 是发挥胃保护作用的主要成分。此外，EV 的分泌有利于[成分名称]发挥胃保护作用。因此，EV 通过降低炎症反应和增强抗氧化功能介导了[成分名称]对乙醇诱导的胃损伤的保护作用，可能是减轻过度炎症性胃肠道疾病的一种有效的抗炎和抗氧化策略。

重要性

本研究表明，[成分名称]对大鼠胃损伤具有保护作用，涉及改善黏膜糖蛋白的产生、抗氧化功能和炎症反应。此外，我们证实了[成分名称]培养的三种生物活性成分（失活的[成分名称]、细胞外囊泡和 EV 无细胞上清液）也有助于发挥胃保护作用。重要的是，[成分名称]衍生的 EVs 对胃保护作用具有有效影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43dc/10986489/504fd2d3057c/spectrum.03894-23.f008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43dc/10986489/ec647494daf1/spectrum.03894-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43dc/10986489/1f4a8c1527fe/spectrum.03894-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43dc/10986489/0ba5f608d67f/spectrum.03894-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43dc/10986489/6a5e40bf2f85/spectrum.03894-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43dc/10986489/7f1a8507211f/spectrum.03894-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43dc/10986489/6163ed578320/spectrum.03894-23.f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43dc/10986489/bcd3458b5ce2/spectrum.03894-23.f007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43dc/10986489/504fd2d3057c/spectrum.03894-23.f008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43dc/10986489/ec647494daf1/spectrum.03894-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43dc/10986489/1f4a8c1527fe/spectrum.03894-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43dc/10986489/0ba5f608d67f/spectrum.03894-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43dc/10986489/6a5e40bf2f85/spectrum.03894-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43dc/10986489/7f1a8507211f/spectrum.03894-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43dc/10986489/6163ed578320/spectrum.03894-23.f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43dc/10986489/bcd3458b5ce2/spectrum.03894-23.f007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43dc/10986489/504fd2d3057c/spectrum.03894-23.f008.jpg

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