Hsieh Shu-Yu, Lian Yu Zhi, Lin I-Hsuan, Yang Yu-Chen, Tinkov Alexey A, Skalny Anatoly V, Chao Jane C-J
School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, 11031, Taiwan.
Research Center of Translational Medicine, Taipei Medical University, Taipei 110, Taiwan.
Nutr Metab (Lond). 2021 Jan 6;18(1):4. doi: 10.1186/s12986-020-00538-9.
Non-steroidal anti-inflammatory drugs such as aspirin are used for the treatment of cardiovascular disease. Chronic use of low-dose aspirin is associated with the occurrence of gastric ulcer. The aim of this study was to investigate the healing potential of Lycium barbarum polysaccharides (LBP) from Chinese Goji berry and C-phycocyanin (CPC) from Spirulina platensis on gastric ulcer in rats.
Male Sprague-Dawley rats were divided into five groups: normal, aspirin (700 mg/kg bw), LBP (aspirin + 100 mg/kg bw/d LBP), CPC (aspirin + 50 mg/kg bw/d CPC), and MIX (aspirin + 50 mg/kg bw/d LBP + 25 mg/kg bw/d CPC) groups. Gastric ulcer was developed by daily oral feeding of aspirin for 8 weeks. Treatments were given orally a week before ulcer induction for 9 weeks.
The MIX group elevated gastric cyclooxygenase-1, prostaglandin E, and total nitrite and nitrate levels by 139%, 86%, and 66%, respectively, compared with the aspirin group (p < 0.05). Moreover, the MIX group reduced lipid peroxides malondialdehyde levels by 78% (p < 0.05). The treatment of LBP and/or CPC increased gastric Bifidobacterium relative abundance by 2.5-4.0 times compared with the aspirin group (p < 0.05).
We conclude that combined LBP and CPC enhance gastroprotective factors, inhibit lipid peroxidation, and increase gastric Bifidobacterium relative abundance. Combined LBP and CPC have protective potential against gastric ulcer caused by aspirin in rats.
阿司匹林等非甾体抗炎药用于治疗心血管疾病。长期使用低剂量阿司匹林与胃溃疡的发生有关。本研究旨在探讨枸杞多糖（LBP）和钝顶螺旋藻藻蓝蛋白（CPC）对大鼠胃溃疡的愈合潜力。
将雄性Sprague-Dawley大鼠分为五组：正常组、阿司匹林组（700mg/kg体重）、LBP组（阿司匹林+100mg/kg体重/天LBP）、CPC组（阿司匹林+50mg/kg体重/天CPC）和混合组（阿司匹林+50mg/kg体重/天LBP+25mg/kg体重/天CPC）。通过每日口服阿司匹林8周诱导胃溃疡。在溃疡诱导前一周开始口服给药，持续9周。
与阿司匹林组相比，混合组胃环氧化酶-1、前列腺素E和总亚硝酸盐及硝酸盐水平分别升高了139%、86%和66%（p<0.05）。此外，混合组脂质过氧化物丙二醛水平降低了78%（p<0.05）。与阿司匹林组相比，LBP和/或CPC治疗使胃双歧杆菌相对丰度增加了2.5-4.0倍（p<0.05）。
我们得出结论，LBP和CPC联合使用可增强胃保护因子，抑制脂质过氧化，并增加胃双歧杆菌相对丰度。LBP和CPC联合使用对大鼠阿司匹林所致胃溃疡具有保护潜力。
