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Conformational dynamics as an intrinsic determinant of prion protein misfolding and neurotoxicity.

作者信息

Cembran Alessandro, Fernandez-Funez Pedro

机构信息

Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, MN, USA.

Department of Biomedical Sciences, University of Minnesota Medical School, Duluth Campus, Duluth, MN, USA.

出版信息

Neural Regen Res. 2024 Oct 1;19(10):2095-2096. doi: 10.4103/1673-5374.391332. Epub 2023 Dec 21.

DOI:10.4103/1673-5374.391332
PMID:38488535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11034596/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc6/11034596/059b35b69da8/NRR-19-2095-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc6/11034596/059b35b69da8/NRR-19-2095-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc6/11034596/059b35b69da8/NRR-19-2095-g001.jpg

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本文引用的文献

1
Intrinsic determinants of prion protein neurotoxicity in : from sequence to (dys)function.朊病毒蛋白神经毒性的内在决定因素:从序列到(功能)失调。
Front Mol Neurosci. 2023 Aug 14;16:1231079. doi: 10.3389/fnmol.2023.1231079. eCollection 2023.
2
Y225A induces long-range conformational changes in human prion protein that are protective in Drosophila.Y225A 诱导人朊病毒蛋白发生长程构象变化,从而对果蝇具有保护作用。
J Biol Chem. 2023 Jul;299(7):104881. doi: 10.1016/j.jbc.2023.104881. Epub 2023 Jun 2.
3
New Drosophila models to uncover the intrinsic and extrinsic factors that mediate the toxicity of the human prion protein.
新的果蝇模型揭示介导人类朊病毒蛋白毒性的内在和外在因素。
Dis Model Mech. 2022 Apr 1;15(4). doi: 10.1242/dmm.049184. Epub 2022 May 3.
4
Dogs are resistant to prion infection, due to the presence of aspartic or glutamic acid at position 163 of their prion protein.狗对朊病毒感染具有抗性,这是由于其朊病毒蛋白的 163 位存在天冬氨酸或谷氨酸。
FASEB J. 2020 Mar;34(3):3969-3982. doi: 10.1096/fj.201902646R. Epub 2020 Jan 15.
5
D159 and S167 are protective residues in the prion protein from dog and horse, two prion-resistant animals.D159 和 S167 是来自对朊病毒有抗性的狗和马的朊病毒蛋白中的保护残基。
Neurobiol Dis. 2018 Nov;119:1-12. doi: 10.1016/j.nbd.2018.07.011. Epub 2018 Jul 24.
6
Structural plasticity of the cellular prion protein and implications in health and disease.细胞朊病毒蛋白的结构可塑性及其在健康和疾病中的意义。
Proc Natl Acad Sci U S A. 2013 May 21;110(21):8549-54. doi: 10.1073/pnas.1306178110. Epub 2013 May 6.
7
Horse prion protein NMR structure and comparisons with related variants of the mouse prion protein.马朊蛋白 NMR 结构与鼠朊蛋白相关变异体的比较。
J Mol Biol. 2010 Jul 9;400(2):121-8. doi: 10.1016/j.jmb.2010.04.066. Epub 2010 May 8.
8
Prion protein NMR structures of cats, dogs, pigs, and sheep.猫、狗、猪和羊的朊病毒蛋白核磁共振结构
Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):640-5. doi: 10.1073/pnas.0408937102. Epub 2005 Jan 12.
9
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.α-螺旋转变为β-折叠是羊瘙痒病朊病毒蛋白形成过程的特征。
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):10962-6. doi: 10.1073/pnas.90.23.10962.