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生长激素促进下丘脑-神经垂体系统中受损轴突的重建。

Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system.

作者信息

Li Kai, Feng Zhanpeng, Xiong Zhiwei, Pan Jun, Zhou Mingfeng, Li Weizhao, Ou Yichao, Wu Guangsen, Che Mengjie, Gong Haodong, Peng Junjie, Wang Xingqin, Qi Songtao, Peng Junxiang

机构信息

Department of Neurosurgery, Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.

出版信息

Neural Regen Res. 2024 Oct 1;19(10):2249-2258. doi: 10.4103/1673-5374.389358. Epub 2023 Nov 8.

DOI:10.4103/1673-5374.389358
PMID:38488559
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11034602/
Abstract

JOURNAL/nrgr/04.03/01300535-202410000-00026/figure1/v/2024-02-06T055622Z/r/image-tiff Previous studies have shown that growth hormone can regulate hypothalamic energy metabolism, stress, and hormone release. Therefore, growth hormone has great potential for treating hypothalamic injury. In this study, we established a specific hypothalamic axon injury model by inducing hypothalamic pituitary stalk electric lesions in male mice. We then treated mice by intraperitoneal administration of growth hormone. Our results showed that growth hormone increased the expression of insulin-like growth factor 1 and its receptors, and promoted the survival of hypothalamic neurons, axonal regeneration, and vascular reconstruction from the median eminence through the posterior pituitary. Altogether, this alleviated hypothalamic injury-caused central diabetes insipidus and anxiety. These results suggest that growth hormone can promote axonal reconstruction after hypothalamic injury by regulating the growth hormone-insulin-like growth factor 1 axis.

摘要

期刊/nrgr/04.03/01300535 - 202410000 - 00026/figure1/v/2024 - 02 - 06T055622Z/r/image - tiff 先前的研究表明，生长激素可调节下丘脑的能量代谢、应激和激素释放。因此，生长激素在治疗下丘脑损伤方面具有巨大潜力。在本研究中，我们通过诱导雄性小鼠下丘脑垂体柄电损伤建立了一种特定的下丘脑轴突损伤模型。然后我们通过腹腔注射生长激素对小鼠进行治疗。我们的结果表明，生长激素增加了胰岛素样生长因子1及其受体的表达，并促进了下丘脑神经元的存活、轴突再生以及从中位隆起经垂体后叶的血管重建。总之，这减轻了下丘脑损伤所致的中枢性尿崩症和焦虑。这些结果表明，生长激素可通过调节生长激素 - 胰岛素样生长因子1轴促进下丘脑损伤后的轴突重建。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69c/11034602/30770737ee43/NRR-19-2249-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69c/11034602/efc0f82c27c5/NRR-19-2249-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69c/11034602/5922f34cc9de/NRR-19-2249-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69c/11034602/65742118eda8/NRR-19-2249-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69c/11034602/4d6b29a128d0/NRR-19-2249-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69c/11034602/3efca6e6b134/NRR-19-2249-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69c/11034602/15b79cf2da92/NRR-19-2249-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69c/11034602/30770737ee43/NRR-19-2249-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69c/11034602/efc0f82c27c5/NRR-19-2249-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69c/11034602/5922f34cc9de/NRR-19-2249-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69c/11034602/65742118eda8/NRR-19-2249-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69c/11034602/4d6b29a128d0/NRR-19-2249-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69c/11034602/3efca6e6b134/NRR-19-2249-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69c/11034602/15b79cf2da92/NRR-19-2249-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69c/11034602/30770737ee43/NRR-19-2249-g008.jpg

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