Department of Obstetrics, China-Japan Union hospital of Jilin University, Changchun, Jilin, China.
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province, China.
Crit Rev Microbiol. 2024 Sep;50(5):937-954. doi: 10.1080/1040841X.2024.2320247. Epub 2024 Mar 15.
The uterine environment provides necessary conditions for the existence of endometrial microbiota, which in turn plays an important role in maintaining the homeostasis of the uterine environment. The endometrial microbiome is highly susceptible to external factors such as age, hormones, menstrual, pregnancy, etc. When the microbiota is imbalanced, it will further promote the occurrence of uterine diseases such as endometritis and endometrial cancer. Regulating the microbiome of the endometrium is of positive significance for promoting uterine health. Among them, antibiotics, probiotics, prebiotics, and microbial transplantation may be important pathways for regulating endometrial microbiota in the future. However, there is currently no unified plan for evaluating the endometrial microbiota. In addition, due to the small sample size, it is easy to be contaminated by exogenous bacterial DNA, which poses great challenges for studying the mechanism of microbial community regulating uterine health. Therefore, there are still many areas worth exploring for the future of endometrial microbiome.
子宫环境为子宫内膜微生物群的存在提供了必要条件，而后者在维持子宫环境的动态平衡中起着重要作用。子宫内膜微生物组极易受到年龄、激素、月经、妊娠等外部因素的影响。当微生物群失衡时，它将进一步促进子宫内膜炎和子宫内膜癌等子宫疾病的发生。调节子宫内膜微生物组对于促进子宫健康具有积极意义。其中，抗生素、益生菌、益生元和微生物移植可能是未来调节子宫内膜微生物组的重要途径。然而，目前还没有统一的子宫内膜微生物组评估计划。此外，由于样本量小，容易被外源细菌 DNA 污染，这给研究微生物群落调节子宫健康的机制带来了巨大挑战。因此，未来子宫内膜微生物组仍有许多值得探索的领域。
