V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
Department of Comparative Cardiology, Federal Research Center Komi Scientific Center, Ural Branch of the Russian Academy of Sciences, Syktyvkar, Komi Republic, Russia.
Bull Exp Biol Med. 2024 Feb;176(4):428-432. doi: 10.1007/s10517-024-06040-z. Epub 2024 Mar 15.
The body surface potential mapping of the heart during the period of ventricular depolarization and the inotropic function of the ventricles were studied in rats under conditions of a translational model of post-infarction chronic heart failure developed by us. We revealed a statistically significant (p<0.001) correlation between the left-ventricular ejection fraction and the values of the maximum positive and negative extrema of the cardioelectric field on the body surface of rats with post-infarction chronic heart failure caused by anterior transmural myocardial infarction. The calculated linear regression equations have high predictive efficiency, which makes it possible to use the amplitude characteristics of the heart cardioelectric field as a marker of the development of chronic heart failure.
在我们建立的心肌梗死后慢性心力衰竭平移模型大鼠中，研究了心室去极化期间心脏体表电势图和心室变力功能。我们揭示了左心室射血分数与体表心电场最大正、负极值值之间存在显著的统计学相关性（p<0.001）。对于前壁透壁性心肌梗死引起的心肌梗死后慢性心力衰竭大鼠，计算出的线性回归方程具有较高的预测效率，这使得可以将心脏心电场的幅度特征用作慢性心力衰竭发展的标志物。
