UOC Ginecologia Oncologica, Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS.
Università Cattolica del Sacro Cuore.
Int J Surg. 2024 Jun 1;110(6):3641-3653. doi: 10.1097/JS9.0000000000001318.
Indocyanine green (ICG), a well-known molecule employed in medicine for over five decades, has emerged as a versatile dye widely embraced across various surgical disciplines. In gynecologic oncology, its prevalent use revolves around the detection of sentinel lymph nodes. However, the true potential of ICG extends beyond this singular application, owing to its pragmatic utility, cost-effectiveness, and safety profile. Furthermore, ICG has been introduced in the theranostic landscape, marking a significant juncture in the evolution of its clinical utility. This narrative review aims to describe the expanding horizons of ICG fluorescence in gynecologic oncology, beyond the sentinel lymph node biopsy. The manifold applications reported within this manuscript include: 1) lymphography; 2) angiography; 3) nerve visualization; 4) ICG-driven resections; and 5) theranostic. The extensive exploration across these numerous applications, some of which are still in the preclinical phase, serves as a hypothesis generator, aiming to stimulate the development of clinical studies capable of expanding the use of this drug in our field, enhancing the care of gynecological cancer patients.
吲哚菁绿（ICG）是一种在医学领域应用了五十多年的知名分子，已成为一种广泛应用于各种外科领域的多功能染料。在妇科肿瘤学中，它的主要用途是检测前哨淋巴结。然而，由于其实际效用、成本效益和安全特性，ICG 的真正潜力远不止于此。此外，ICG 已被引入治疗诊断领域，标志着其临床应用的重大进展。本综述旨在描述 ICG 荧光在妇科肿瘤学中的应用不断扩大，不仅仅局限于前哨淋巴结活检。本文报道的多种应用包括：1）淋巴造影术；2）血管造影术；3）神经可视化；4）ICG 驱动的切除术；5）治疗诊断。对这些广泛应用的深入探索，其中一些仍处于临床前阶段，旨在为临床研究提供假设，这些研究有可能扩大这种药物在我们领域的应用，从而改善妇科癌症患者的护理。
