School of Public Health & Laboratory Medicine, Hunan University of Medicine, Huaihua, China.
Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, Hunan University of Medicine, Huaihua, China.
Medicine (Baltimore). 2024 Mar 15;103(11):e37496. doi: 10.1097/MD.0000000000037496.
CD8+ T cells have great roles in tumor suppression and elimination of various tumors including hepatocellular carcinoma (HCC). Nonetheless, potential prognostic roles of CD8+ T cell-related genes (CD8Gs) in HCC remains unknown. In our study, 416 CD8Gs were identified in HCC, which were enriched in inflammatory and immune signaling pathways. Using The Cancer Genome Atlas dataset, a 5-CD8Gs risk model (KLRB1, FYN, IL2RG, FCER1G, and DGKZ) was constructed, which was verified in International Cancer Genome Consortium and gene expression omnibus datasets. Furthermore, we found that overall survival was independently correlated with the CD8Gs signature, and it was associated with immune- and cancer-related signaling pathways and immune cells infiltration. Finally, drug sensitivity data indicated that 10 chemotherapeutic drugs held promise as therapeutics for HCC patients with high-risk. In conclusion, multi-databases analysis showed that 5-CD8Gs and their signature could be an indicator to predict candidate drugs for HCC therapy.
CD8+ T 细胞在肿瘤抑制和消除包括肝细胞癌（HCC）在内的各种肿瘤方面发挥着重要作用。然而，CD8+ T 细胞相关基因（CD8Gs）在 HCC 中的潜在预后作用尚不清楚。在我们的研究中，在 HCC 中鉴定出 416 个 CD8Gs，它们富集在炎症和免疫信号通路中。使用癌症基因组图谱数据集，构建了一个 5-CD8Gs 风险模型（KLRB1、FYN、IL2RG、FCER1G 和 DGKZ），并在国际癌症基因组联盟和基因表达综合数据集得到验证。此外，我们发现总生存期与 CD8Gs 特征独立相关，与免疫和癌症相关的信号通路以及免疫细胞浸润有关。最后，药物敏感性数据表明，10 种化疗药物有望成为高危 HCC 患者的治疗药物。总之，多数据库分析表明，5-CD8Gs 及其特征可以作为预测 HCC 治疗候选药物的指标。
