Ptak Radek, Bourgeois Alexia
Laboratory of Cognitive Neurorehabilitation, Faculty of Medicine, University of Geneva, Geneva 1206, Switzerland; Division of Neurorehabilitation, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, Geneva 1205, Switzerland.
Laboratory of Cognitive Neurorehabilitation, Faculty of Medicine, University of Geneva, Geneva 1206, Switzerland; University of Applied Sciences and Arts of Western Switzerland, School of Health Sciences, Avenue de Champel 47, Geneva 1206, Switzerland.
Neurosci Biobehav Rev. 2024 May;160:105622. doi: 10.1016/j.neubiorev.2024.105622. Epub 2024 Mar 13.
The present review examined the consequences of focal brain injury on spatial attention studied with cueing paradigms, with a particular focus on the disengagement deficit, which refers to the abnormal slowing of reactions following an ipsilesional cue. Our review supports the established notion that the disengagement deficit is a functional marker of spatial neglect and is particularly pronounced when elicited by peripheral cues. Recent research has revealed that this deficit critically depends on cues that have task-relevant characteristics or are associated with negative reinforcement. Attentional capture by task-relevant cues is contingent on damage to the right temporo-parietal junction (TPJ) and is modulated by functional connections between the TPJ and the right insular cortex. Furthermore, damage to the dorsal premotor or prefrontal cortex (dPMC/dPFC) reduces the effect of task-relevant cues. These findings support an interactive model of the disengagement deficit, involving the right TPJ, the insula, and the dPMC/dPFC. These interconnected regions play a crucial role in regulating and adapting spatial attention to changing intrinsic values of stimuli in the environment.
本综述研究了使用线索范式对局灶性脑损伤后空间注意力的影响，特别关注脱离缺陷，即同侧线索后反应异常减慢。我们的综述支持已有的观点，即脱离缺陷是空间忽视的功能标志物，并且在外周线索引发时尤为明显。最近的研究表明，这种缺陷严重依赖于具有任务相关特征或与负强化相关的线索。与任务相关线索的注意捕获取决于右侧颞顶联合区（TPJ）的损伤，并受到TPJ与右侧岛叶皮质之间功能连接的调节。此外，背侧运动前区或前额叶皮质（dPMC/dPFC）的损伤会降低与任务相关线索的作用。这些发现支持了一个关于脱离缺陷的交互模型，涉及右侧TPJ、岛叶和dPMC/dPFC。这些相互连接的区域在调节和调整空间注意力以适应环境中刺激不断变化的内在价值方面起着关键作用。
