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Calpain inhibition takes center stage against atrial fibrillation in the diabetic heart.钙蛋白酶抑制在对抗糖尿病心脏中的房颤方面占据核心地位。
Heart Rhythm. 2024 Jul;21(7):1152-1153. doi: 10.1016/j.hrthm.2024.03.024. Epub 2024 Mar 13.
2
Physiologic and pathophysiologic role of calpain: implications for the occurrence of atrial fibrillation.钙蛋白酶的生理和病理生理作用：对心房颤动发生的影响。
Cardiovasc Ther. 2012 Jun;30(3):e115-27. doi: 10.1111/j.1755-5922.2010.00245.x. Epub 2010 Nov 25.
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[Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine].钙蛋白酶I抑制可预防犬心房颤动中起搏诱导的结构重塑
Zhonghua Xin Xue Guan Bing Za Zhi. 2007 Feb;35(2):132-6.
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Calpain in atrial fibrillation: friend or foe?: editorial to: "anti-apoptotic effects of a calpain inhibitor on cardiomyocytes in a canine rapid atrial fibrillation model" by Yue Li et al.
Cardiovasc Drugs Ther. 2009 Oct;23(5):339-40. doi: 10.1007/s10557-009-6200-9.
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[Effect of calpain 1 on structural remodeling and contractile dysfunction in atrial fibrillation: experiment with dogs].钙蛋白酶1对心房颤动结构重塑和收缩功能障碍的影响：犬实验
Zhonghua Yi Xue Za Zhi. 2007 Aug 28;87(32):2285-8.
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Calpain inhibition protects against atrial fibrillation by mitigating diabetes-associated atrial fibrosis and calcium handling dysfunction in type 2 diabetes mice.钙蛋白酶抑制可通过减轻 2 型糖尿病小鼠的糖尿病相关心房纤维化和钙处理功能障碍来预防心房颤动。
Heart Rhythm. 2024 Jul;21(7):1143-1151. doi: 10.1016/j.hrthm.2024.02.036. Epub 2024 Feb 21.
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Calpain I inhibition prevents atrial structural remodeling in a canine model with atrial fibrillation.钙蛋白酶I抑制可预防犬类房颤模型中的心房结构重塑。
Chin Med J (Engl). 2008 Jan 5;121(1):32-7.
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Anti-apoptotic effects of a calpain inhibitor on cardiomyocytes in a canine rapid atrial fibrillation model.钙蛋白酶抑制剂对犬快速心房颤动模型中心肌细胞的抗凋亡作用。
Cardiovasc Drugs Ther. 2009 Oct;23(5):361-8. doi: 10.1007/s10557-009-6199-y.
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Automated blood pressure measurement in atrial fibrillation: a systematic review and meta-analysis.心房颤动中的自动血压测量：系统评价和荟萃分析。
J Hypertens. 2012 Nov;30(11):2074-82. doi: 10.1097/HJH.0b013e32835850d7.
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Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation.钙蛋白酶介导心房颤动时心肌肌钙蛋白降解及收缩功能障碍。
J Mol Cell Cardiol. 2008 Nov;45(5):685-93. doi: 10.1016/j.yjmcc.2008.08.012. Epub 2008 Sep 11.

本文引用的文献

1
Calpain inhibition protects against atrial fibrillation by mitigating diabetes-associated atrial fibrosis and calcium handling dysfunction in type 2 diabetes mice.钙蛋白酶抑制可通过减轻 2 型糖尿病小鼠的糖尿病相关心房纤维化和钙处理功能障碍来预防心房颤动。
Heart Rhythm. 2024 Jul;21(7):1143-1151. doi: 10.1016/j.hrthm.2024.02.036. Epub 2024 Feb 21.
2
2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.2024 年心脏病与中风统计数据：美国心脏协会发布的美国和全球数据报告。
Circulation. 2024 Feb 20;149(8):e347-e913. doi: 10.1161/CIR.0000000000001209. Epub 2024 Jan 24.
3
Structure, Function, and Regulation of the Junctophilin Family.连接素蛋白家族的结构、功能与调控
Annu Rev Physiol. 2024 Feb 12;86:123-147. doi: 10.1146/annurev-physiol-042022-014926. Epub 2023 Nov 6.
4
CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia.钙调蛋白依赖性蛋白激酶 II 丝氨酸 280 O-连接的 N-乙酰葡萄糖胺修饰将糖尿病高血糖与致心律失常联系起来。
Circ Res. 2021 Jun 25;129(1):98-113. doi: 10.1161/CIRCRESAHA.120.318402. Epub 2021 Apr 30.
5
Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms.氧化型 CaMKII 和 O-GlcNAc 糖化通过不同的机制导致糖尿病小鼠心房颤动的增加。
J Clin Invest. 2021 Jan 19;131(2). doi: 10.1172/JCI95747.
6
Targeting Calpain for Heart Failure Therapy: Implications From Multiple Murine Models.靶向钙蛋白酶用于心力衰竭治疗：来自多个小鼠模型的启示
JACC Basic Transl Sci. 2018 Aug 28;3(4):503-517. doi: 10.1016/j.jacbts.2018.05.004. eCollection 2018 Aug.
7
Eplerenone Reduces Atrial Fibrillation Burden Without Preventing Atrial Electrical Remodeling.依普利酮可减轻房颤负荷，但不能预防心房电重构。
J Am Coll Cardiol. 2017 Dec 12;70(23):2893-2905. doi: 10.1016/j.jacc.2017.10.014.
8
Atrial Calpains: Mediators of Atrialmyopathies in Atrial Fibrillation.心房钙蛋白酶：心房颤动中心房肌病的介质
J Atr Fibrillation. 2014 Apr 30;6(6):1021. doi: 10.4022/jafib.1021. eCollection 2014 Apr-May.
9
Over-expression of calpastatin inhibits calpain activation and attenuates post-infarction myocardial remodeling.钙蛋白酶抑制蛋白的过表达可抑制钙蛋白酶的激活，并减轻梗死后心肌重塑。
PLoS One. 2015 Mar 18;10(3):e0120178. doi: 10.1371/journal.pone.0120178. eCollection 2015.
10
Dominant frequency increase rate predicts transition from paroxysmal to long-term persistent atrial fibrillation.主导频率增加率可预测阵发性到长期持续性心房颤动的转变。
Circulation. 2014 Apr 8;129(14):1472-82. doi: 10.1161/CIRCULATIONAHA.113.004742. Epub 2014 Jan 24.

Calpain inhibition takes center stage against atrial fibrillation in the diabetic heart.

作者信息

Ríos-Pérez Erick B, Alvarado Francisco J

机构信息

Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

出版信息

Heart Rhythm. 2024 Jul;21(7):1152-1153. doi: 10.1016/j.hrthm.2024.03.024. Epub 2024 Mar 13.

DOI:10.1016/j.hrthm.2024.03.024
PMID:38490602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11222044/
Abstract
摘要