L.K. Stamp, PhD, Department of Medicine, University of Otago, Christchurch;
N. Dalbeth, MD, Faculty of Medicine, University of Auckland, Auckland, New Zealand.
J Rheumatol. 2024 Jun 1;51(6):556-562. doi: 10.3899/jrheum.2024-0144.
Allopurinol is the most widely used urate-lowering medication worldwide. However, allopurinol failure is frequently observed in clinical practice. In this review, we provide a framework for assessing allopurinol failure, which includes failure of allopurinol to control serum urate concentrations, failure of allopurinol to control clinical symptoms, and failure of allopurinol due to an adverse drug reaction. Understanding the causes of allopurinol failure underpins the approach required to turn failure into success in gout management.
别嘌醇是全球应用最广泛的降尿酸药物。然而，别嘌醇在临床实践中经常出现失败。在这篇综述中，我们提供了一种评估别嘌醇失败的框架，包括别嘌醇未能控制血清尿酸浓度、别嘌醇未能控制临床症状以及别嘌醇因药物不良反应而失败。了解别嘌醇失败的原因是实现痛风管理从失败到成功所需方法的基础。
