FIRRM 和 FIGNL1：同源重组调控中的合作伙伴。

FIRRM and FIGNL1: partners in the regulation of homologous recombination.

机构信息

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713GZ, Groningen, The Netherlands.

出版信息

Trends Genet. 2024 Jun;40(6):467-470. doi: 10.1016/j.tig.2024.02.007. Epub 2024 Mar 16.

DOI:10.1016/j.tig.2024.02.007

PMID:38494375

Abstract

DNA repair through homologous recombination (HR) is of vital importance for maintaining genome stability and preventing tumorigenesis. RAD51 is the core component of HR, catalyzing the strand invasion and homology search. Here, we highlight recent findings on FIRRM and FIGNL1 as regulators of the dynamics of RAD51.

摘要

通过同源重组（HR）进行 DNA 修复对于维持基因组稳定性和预防肿瘤发生至关重要。RAD51 是 HR 的核心组成部分，催化链入侵和同源搜索。在这里，我们强调了 FIRRM 和 FIGNL1 作为 RAD51 动力学调节剂的最新发现。