University of California, Riverside, USA.
Eisenhower Health, Rancho Mirage, CA, USA.
J Investig Med High Impact Case Rep. 2024 Jan-Dec;12:23247096241238531. doi: 10.1177/23247096241238531.
Extranodal marginal zone B-cell lymphoma (ENMZL) of mucosa-associated lymphoid tissue (MALT), a rare subtype of B-cell lymphoma, is typically associated with () infection, especially in gastric cases. However, this article presents 2 unique cases of -negative colonic ENMZL, challenging the conventional understanding of the disease. The first case involves an 80-year-old male diagnosed with Stage 1E ENMZL in the descending colon, and the second describes a 74-year-old male with sigmoid colon ENMZL. Both cases lacked infection, adding complexity to their management. Accompanying these case studies is a comprehensive literature review, delving into the epidemiology, pathology, clinical features, diagnosis, and treatment of -negative ENMZL, with a focus on gastrointestinal involvement. This review highlights the importance of considering -negative cases in ENMZL diagnosis and management, illustrating the need for further research and individualized treatment approaches in this uncommon lymphoma subtype.
黏膜相关淋巴组织（MALT）结外边缘区 B 细胞淋巴瘤（ENMZL）是一种罕见的 B 细胞淋巴瘤亚型，通常与 感染相关，尤其是在胃部病例中。然而，本文介绍了 2 例独特的结肠 ENMZL 病例，呈 - 阴性，这对该疾病的传统认知提出了挑战。第一个病例涉及一名 80 岁男性，被诊断为降结肠 1E 期 ENMZL；第二个病例描述了一名 74 岁男性，患有乙状结肠 ENMZL。这两个病例均无 感染，这使得它们的管理更加复杂。这两个病例伴随着全面的文献综述，深入探讨了 - 阴性 ENMZL 的流行病学、病理学、临床特征、诊断和治疗，重点关注胃肠道受累。这篇综述强调了在 ENMZL 诊断和管理中考虑 - 阴性病例的重要性，说明需要对这种罕见的淋巴瘤亚型进行进一步的研究和个体化治疗方法。
