Chen Feng, Wu Shan-Shan, Chen Chao, Zhou Cheng
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
World J Hepatol. 2024 Feb 27;16(2):177-185. doi: 10.4254/wjh.v16.i2.177.
Lipocalin 2 (LCN2) plays a pivotal role in iron metabolism, particularly in the context of microbial infection resistance (, viruses, bacteria, parasites, ). LCN2 combats microbial infection by directly assisting the body in competing with microorganisms for iron, inducing immune cells to secrete various cytokines to enhance systemic immune responses, or recruiting neutrophils to infectious sites. The liver serves as the primary organ for LCN2 secretion during microbial infections. This review encapsulates recent advances in dynamic changes, clinical values, and the effects of LCN2 in infectious liver diseases caused by various microbial microorganisms.
脂联素2（LCN2）在铁代谢中起关键作用，尤其是在抵抗微生物感染（病毒、细菌、寄生虫等）方面。LCN2通过直接帮助机体与微生物竞争铁、诱导免疫细胞分泌各种细胞因子以增强全身免疫反应或招募中性粒细胞至感染部位来对抗微生物感染。在微生物感染期间，肝脏是LCN2分泌的主要器官。本文综述了LCN2在各种微生物引起的感染性肝病中的动态变化、临床价值及作用的最新进展。
