Beard Victoria, Ghawji Maher, Salman Fariha, Oktaei Hooman
Department of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
JCEM Case Rep. 2024 Mar 15;2(3):luae027. doi: 10.1210/jcemcr/luae027. eCollection 2024 Mar.
Pheochromocytomas are rare catecholamine-secreting tumors that occur in 0.002% of pregnancies. These tumors result in high maternal and fetal morbidity and mortality unless diagnosed in early stages of development, because excess levels of catecholamines cause vasoconstriction of both maternal and uteroplacental vasculature. Paroxysmal hypertension is the most common manifestation, but its variability in presentation and similarity to other pregnancy-related conditions often make diagnosis of pheochromocytoma difficult. Thus, it is essential to consider underlying pathological causes of hypertension during gestation. Diagnosis and treatment of pheochromocytoma must be approached uniquely given the physiologic changes during pregnancy. The standard of care for diagnostic imaging during pregnancy is with magnetic resonance imaging. For these reasons, knowledge of therapy for pheochromocytomas in the pregnant patient is essential for clinical endocrinology practice.
嗜铬细胞瘤是一种罕见的分泌儿茶酚胺的肿瘤，在0.002%的妊娠中发生。这些肿瘤会导致高孕产妇和胎儿发病率及死亡率，除非在发育早期被诊断出来，因为过量的儿茶酚胺会导致母体和子宫胎盘血管收缩。阵发性高血压是最常见的表现，但其表现的变异性以及与其他妊娠相关疾病的相似性常常使嗜铬细胞瘤的诊断变得困难。因此，在妊娠期必须考虑高血压的潜在病理原因。鉴于孕期的生理变化，嗜铬细胞瘤的诊断和治疗必须采取独特的方法。孕期诊断性成像的护理标准是使用磁共振成像。出于这些原因，了解妊娠患者嗜铬细胞瘤的治疗方法对于临床内分泌学实践至关重要。
