Clin Nephrol. 2024 Jun;101(6):271-276. doi: 10.5414/CN111179.
Hemodialysis patients have high COVID-19 severity and mortality rates. For this high-risk group of hemodialysis patients with SARS-CoV-2 infection, early SARS-CoV-2 vaccination is recommended to prevent infection and severe disease. Thus far, few reports have evaluated COVID-19 antibody titers in hemodialysis patients. In this study, we investigated the time course of antibody titers acquired by vaccination in patients on dialysis.
The anti-SARS-CoV-2 spike protein S1 IgG (anti-SP-IgG) antibody titers were compared between 33 outpatient maintenance hemodialysis patients and 32 age- and sex-matched healthy subjects. Antibody tests were performed at five time points: 6 months after the 2 vaccination, immediately before the 3 vaccination (8 months after the 2 vaccination), and 2 weeks, 1 month, and 3 months after the 3 vaccination.
The dialysis patient group had significantly lower values of anti-SP-IgG antibody titers than the control group 6 months after the 2 vaccination (433.7 ± 36.24 vs. 650.2 (427.2 - 759.4) (AU/mL), p = 0.006) and immediately before the 3 vaccination (219.3 (129.4 - 423.4) vs. 443.3 (267.1 - 600.4) (AU/mL), p = 0.034), but no significant differences were observed after the 3 vaccination (19,000.0 (11,000.0 - 3,6000.0) vs. 23,500.0 (20,250.0 - 29,000.0) (AU/mL), p = 0.538).
This study confirmed that patients undergoing hemodialysis were proven to have acquired sufficient antibody titers after the vaccination.
血液透析患者 COVID-19 严重程度和死亡率较高。对于 SARS-CoV-2 感染的这一高风险血液透析患者群体，建议早期进行 SARS-CoV-2 疫苗接种，以预防感染和重症疾病。迄今为止，很少有报道评估血液透析患者的 COVID-19 抗体滴度。在这项研究中，我们研究了透析患者接种疫苗后获得的抗体滴度的时间过程。
比较了 33 名门诊维持性血液透析患者和 32 名年龄和性别匹配的健康对照者的抗 SARS-CoV-2 刺突蛋白 S1 IgG（抗 SP-IgG）抗体滴度。在五个时间点进行抗体检测：接种 2 剂后 6 个月、接种 3 剂前即刻（接种 2 剂后 8 个月）以及接种 3 剂后 2 周、1 个月和 3 个月。
与对照组相比，透析患者组在接种 2 剂后 6 个月（433.7 ± 36.24 比 650.2（427.2 - 759.4）（AU/mL），p = 0.006）和接种 3 剂前即刻（219.3（129.4 - 423.4）比 443.3（267.1 - 600.4）（AU/mL），p = 0.034）的抗 SP-IgG 抗体滴度明显较低，但接种 3 剂后无显著差异（19,000.0（11,000.0 - 3,6000.0）比 23,500.0（20,250.0 - 29,000.0）（AU/mL），p = 0.538）。
本研究证实，接受血液透析的患者接种疫苗后可获得足够的抗体滴度。
