Department of Biochemistry & Molecular Biology, Federal University of Ceará, Fortaleza, CE, 60451-970, Brazil.
University of Brasília, Post-Graduation in Molecular Pathology, Darcy Ribeiro Campus, Brasília, DF, 70910-900, Brazil.
Future Microbiol. 2024;19(7):621-630. doi: 10.2217/fmb-2023-0236. Epub 2024 Mar 18.
Antifungal infections are becoming a major concern to human health due to antimicrobial resistance. Echinocandins have been promising agents against resistant fungal infections, primarily caspofungin, which has a more effective mechanism of action than azoles and polyenes. However, fungi such as appear to be inheritably resistant to these drugs, which is concerning due to the high clinical importance of . In this review, we review the history of and the treatments used to treat antifungals over the years, focusing on caspofungin, while highlighting the problem and possible explanations for its inherent resistance.
由于抗菌药物耐药性的出现,抗真菌感染已成为人类健康的一大关注点。棘白菌素类药物一直是治疗耐药真菌感染的有希望的药物,其中尤以卡泊芬净为甚,其作用机制比唑类和多烯类更为有效。然而,某些真菌,如 ,似乎对这些药物具有固有耐药性,这令人担忧,因为 具有重要的临床意义。在这篇综述中,我们回顾了 和多年来用于治疗抗真菌药物的治疗方法,重点介绍了卡泊芬净,同时强调了 的问题及其固有耐药性的可能解释。