Brown B L, Neel H B, Kern E B
Arch Otolaryngol. 1979 Oct;105(10):605-9. doi: 10.1001/archotol.1979.00790220039010.
Four types of synthetic materials were implanted in 54 rabbits: Supramid, Proplast, Plasti-Pore, and Silastic. Each material was implanted into the auricle and concomitantly into the subdermis of the face. Postoperative assessment was every one to three days, while killing was done at six weeks, six months, and one year postoperatively for microscopic evaluation. Supramid mesh contains black pigment, which became incorporated within the histiocytes and giant cells around the implanted mesh by six weeks; at one year, the soft tissues were pigmented microscopically. Proplast was not extruded despite an intense and persistent histiocytic and giant-cell reaction; its black color constituted a major drawback for implantation beneath thin skin. The Plasti-Pore used in these studies was rigid and somewhat difficult to sculpture, and it induced a persistent but minor cellular reaction. Silastic was easily displaced.
将四种合成材料植入54只兔子体内：Supramid、Proplast、Plasti - Pore和硅橡胶。每种材料均植入耳廓并同时植入面部皮下。术后每1至3天进行评估，术后6周、6个月和1年处死兔子以进行显微镜评估。Supramid网含有黑色色素，到6周时已被植入网周围的组织细胞和巨细胞摄取；1年后，软组织在显微镜下呈现色素沉着。尽管有强烈且持续的组织细胞和巨细胞反应，Proplast并未被挤出；其黑色是在薄皮肤下植入的一个主要缺点。这些研究中使用的Plasti - Pore质地坚硬，有点难以塑形，并且引发了持续但轻微的细胞反应。硅橡胶很容易移位。
