Wu Xiaomei, Wang Suixiang, Lin Xiaoxiao, Liang Huanzhu, Wu Yingying, Tan Yuxuan, Zeng Huixian, Chen Qian, Wang Jie, Huang Feng, Guo Ziang, Xing Puyi, Nie Jiyu, Yao Huojie, Fu Yingyin, Yang Zhiyu, Zeng Zurui, Xu Hongbiao, Zhong Xingming, Jing Chunxia
Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; Guangdong Key Laboratory of Environmental Exposure and Health, Jinan University, Guangzhou, Guangdong 510632, China.
Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
Reprod Toxicol. 2024 Apr;125:108577. doi: 10.1016/j.reprotox.2024.108577. Epub 2024 Mar 16.
Although there is a body of research indicating the potential impact of polycyclic aromatic hydrocarbons (PAHs) exposure on male infertility, the understanding of how PAH might affect female infertility is still limited. This study aimed to evaluate associations of PAHs, both individually and as a mixture, with female infertility using multiple logistic regression, Bayesian kernel machine regression (BKMR), and quantile g-computation (QGC) models based on data from the National Health and Nutrition Examination Survey (NHANES) 2013-2016. The study included 729 female participants. Multiple logistic regression results indicated that there was a significant association between the third tertile of 2-hydroxy fluorene (2-OHFLU) and female infertility, and the OR was 2.84 (95% CI: 1.24-6.53, P value = 0.015) compared with the first tertile after adjusting for the potential covariates. The BKMR model revealed a positive overall trend between mixed PAH exposure and female infertility, particularly when the mixture was at or above the 55th percentile, where 2-hydroxynaphthalene (2-OHNAP) and 1-hydroxypyrene (1-OHPYR) were the primary influences of the mixture. The univariate exposure-response function indicated positive associations between individual PAH exposure, specifically 2-OHNAP, 2-OHFLU, and 1-OHPYR, and female infertility. The QGC model also indicated a positive trend between exposure to a mixture of PAHs and female infertility, although it did not reach statistical significance (OR = 1.33, 95%CI: 0.86-2.07), with 1-OHPYR having the greatest positive effect on the outcome. This study suggested that exposure to PAHs may be associated with female infertility and further research is needed to consolidate and confirm these findings.
尽管有大量研究表明接触多环芳烃（PAHs）对男性不育有潜在影响，但对于PAH如何影响女性不育的了解仍然有限。本研究旨在利用基于2013 - 2016年美国国家健康与营养检查调查（NHANES）数据的多元逻辑回归、贝叶斯核机器回归（BKMR）和分位数g计算（QGC）模型，评估PAHs单独及混合情况下与女性不育的关联。该研究纳入了729名女性参与者。多元逻辑回归结果表明，在调整潜在协变量后，2 - 羟基芴（2 - OHFLU）第三分位数与女性不育之间存在显著关联，与第一分位数相比，比值比（OR）为2.84（95%置信区间：1.24 - 6.53，P值 = 0.015）。BKMR模型显示混合PAH暴露与女性不育之间存在总体正相关趋势，特别是当混合物处于或高于第55百分位数时，其中2 - 羟基萘（2 - OHNAP）和1 - 羟基芘（1 - OHPYR）是混合物的主要影响因素。单变量暴露 - 反应函数表明个体PAH暴露，特别是2 - OHNAP、2 - OHFLU和1 - OHPYR与女性不育之间存在正相关。QGC模型也表明PAHs混合物暴露与女性不育之间存在正相关趋势，尽管未达到统计学显著性（OR = 1.33，95%置信区间：0.86 - 2.07），其中1 - OHPYR对结果的正向影响最大。本研究表明接触PAHs可能与女性不育有关，需要进一步研究来巩固和证实这些发现。
