大鼠肝脏中肝素可释放脂肪酶的原位定位。
Localization of the heparin-releasable lipase in situ in the rat liver.
作者信息
Kuusi T, Nikklä E A, Virtanen I, Kinnunen P K
出版信息
Biochem J. 1979 Jul 1;181(1):245-6. doi: 10.1042/bj1810245.
Abstract
Immunofluorescence and immuno-electron microscopy were used for the localization of the heparin-releasable lipase in situ in the rat liver. The lipase is located exclusively on the liver endothelial cells. No labelling could be detected on the parenchymal of Kupffer cells, or in the livers of heparin-pretreated animals. The physiological significance of the endothelial localization of the hepatic lipase is discussed.
摘要
采用免疫荧光和免疫电子显微镜技术对大鼠肝脏中肝素可释放脂肪酶进行原位定位。该脂肪酶仅定位于肝内皮细胞。在实质细胞、库普弗细胞或肝素预处理动物的肝脏中均未检测到标记。文中讨论了肝脏脂肪酶在内皮细胞定位的生理意义。
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