Tadesse Gebresilassie, Tinsae Techilo, Nakie Girum, Rtbey Gidey, Andualem Fantahun, Tadesse Asnake, Melkam Mamaru, Takelle Girmaw Medfu, Fentahun Setegn
Department of Psychiatry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Front Neurol. 2024 Feb 28;15:1352648. doi: 10.3389/fneur.2024.1352648. eCollection 2024.
Depression is a major public health problem and negatively affects the quality of life of patients with epilepsy. Despite multiple studies investigating the magnitude and predictors, the results have been inconsistent. Therefore, this study aimed to estimate the pooled prevalence and factors associated with depressive symptoms among patients with epilepsy in Ethiopia.
The primary articles were searched using databases like PubMed, Google Scholar, CINAHL, SCOPUS, EMBASE, and African Journal Online. A total of 10 primary articles that assessed the prevalence and factors associated with depressive symptoms among patients with epilepsy in Ethiopia were included. A Microsoft Excel spreadsheet was used to extract the data, which was then exported to Stata version 14 for further analysis. The statistical heterogeneity was evaluated using the test. Due to heterogeneity, a random effect meta-analysis model was employed. Publication bias was checked through Egger's weighted regression test and funnel plot.
A total of 10 primary studies with 3,532 participants were included. The pooled prevalence of depressive symptoms among patients with epilepsy was found to be 41.69% (95% CI, 37.70, 45.68). The pooled prevalence of depressive symptoms was 48.61, 42.98, 40.68, 38.27, and 34.80% in Oromia, SNNPs, Amhara, Addis Ababa, and Tigray, respectively, based on a sub-group analysis per regional state. Perceived stigma (AOR = 3.30, 95% CI: 1.40, 7.80), seizure frequency (AOR = 3.81, 95% CI: 1.03, 14.09), and perceived stress (AOR = 4.6, 95% CI: 1.05, 20.06) were factors associated with depressive symptoms.
We found that depressive symptoms affects at least four out of ten patients with epilepsy, indicating an immense burden. Depressive symptoms were extremely prevalent in those who had high levels of stigma, a monthly seizure frequency of once or more, and perceived stress. Therefore, physicians should take extra precautions when treating patients with epilepsy who have certain conditions.
This study was registered according to The International Prospective Register of Systemic Review (PROSPERO) with the registration ID (CRD42023484308).
抑郁症是一个重大的公共卫生问题，对癫痫患者的生活质量产生负面影响。尽管有多项研究调查了其严重程度和预测因素，但结果并不一致。因此，本研究旨在估计埃塞俄比亚癫痫患者中抑郁症状的合并患病率及相关因素。
通过PubMed、谷歌学术、CINAHL、SCOPUS、EMBASE和非洲期刊在线等数据库检索原始文章。共纳入10篇评估埃塞俄比亚癫痫患者抑郁症状患病率及相关因素的原始文章。使用Microsoft Excel电子表格提取数据，然后导出到Stata 14版本进行进一步分析。使用 检验评估统计异质性。由于存在异质性，采用随机效应荟萃分析模型。通过Egger加权回归检验和漏斗图检查发表偏倚。
共纳入10项涉及3532名参与者的原始研究。癫痫患者中抑郁症状的合并患病率为41.69%（95%置信区间，37.70，45.68）。根据每个地区州的亚组分析，奥罗米亚、南方各族州、阿姆哈拉、亚的斯亚贝巴和提格雷抑郁症状的合并患病率分别为48.61%、42.98%、40.68%、38.27%和34.80%。感知到的耻辱感（比值比=3.30，95%置信区间：1.40，7.80）、癫痫发作频率（比值比=3.81，95%置信区间：1.03，14.09）和感知到的压力（比值比=4.6，95%置信区间：1.05，20.06）是与抑郁症状相关的因素。
我们发现抑郁症状影响至少十分之四的癫痫患者，表明负担巨大。在那些耻辱感高、每月癫痫发作频率一次或更多以及感知到压力的患者中，抑郁症状极为普遍。因此，医生在治疗患有某些病症的癫痫患者时应格外谨慎。
本研究已根据国际系统评价前瞻性注册库（PROSPERO）进行注册，注册号为（CRD42023484308）。
