Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei City, Taiwan.
Department of Obstetrics and Gynecology, Cardinal Tien Hospital, New Taipei City, Taiwan.
Med Sci Monit. 2024 Mar 8;30:e943400. doi: 10.12659/MSM.943400.
The incidence of miscarriage in early pregnancy, between 5-20 weeks, is common, with a prevalence of between 5-22% of all pregnancies. Miscarriage can have physical, social, and mental health impacts on women and their families. In societies such as Taiwan, where the birth rate is falling and life expectancy is increasing, there is concern that factors that reduce birth rates will have detrimental economic and societal effects. Progesterone has a significant role in maintaining early and successful pregnancy to term. Evidence from preclinical and clinical research on the roles of progesterone has supported recent clinical guidelines in obstetrics and gynecology to reduce rates of early miscarriage and improve methods of assisted reproductive technology (ART). This article aims to present an evidence-based review of current recommendations for the use of progesterone in early pregnancy to reduce miscarriage rates and in luteal phase support for ART, including embryo transfer.
早期妊娠（5-20 周）流产的发生率较高，占所有妊娠的 5-22%。流产会对女性及其家庭的身心健康造成影响。在台湾等出生率下降、预期寿命延长的社会，人们担心降低出生率的因素会对经济和社会产生不利影响。孕激素在维持早期妊娠和成功足月妊娠中起着重要作用。孕激素的临床前和临床研究证据支持了最近妇产科临床指南，以降低早期流产率并改善辅助生殖技术（ART）的方法。本文旨在对当前孕激素在早期妊娠中降低流产率和黄体期支持 ART（包括胚胎移植）的应用建议进行循证综述。
