Lanzhou University, Lanzhou City, Gansu Province, China.
Department of Reproductive Medicine, Lanzhou University Second Hospital, Lanzhou City, 730030, Gansu Province, China.
Sci Rep. 2024 Jul 19;14(1):16657. doi: 10.1038/s41598-024-67744-w.
Establishing prediction models of pregnancy outcomes for recurrent pregnancy loss women at specific gestational weeks will provide patients and physicians with more precise information, ultimately leading to time and cost savings associated with unnecessary revisits. Therefore, our aim was to develop a prediction model for first trimester pregnancy loss in RPL patients. We used ultrasound indices during the first trimester of pregnancy in combination with demographic characteristics and commonly used serum markers. The independent risk factors for each week were as follows: age and P in the fifth week; age, mGSD and CRL in the sixth week; age, hCG and CRL in the seventh week; CRL in the eighth week; mGSD and CRL in ninth week. The corresponding AUC was 0.671, 0.796, 0.872, 0.871, 0.813, respectively. There is a linear relationship between age and first trimester pregnancy loss. hCG < 69,636.6 mIU/ml was associated with a higher risk of pregnancy loss in the seventh gestation week. An mGSD < 18.3 mm, adjusted for age, BMI, and previous pregnancy loss in the sixth week, was linked to an increased risk of first trimester pregnancy loss. A small CRL measurement (less than 2.4 mm, 9.9 mm, 16.9 mm, and 18.6 mm) in the sixth, seventh, eighth and ninth week was closely correlated with higher risk of first trimester pregnancy loss. Furthermore, an mGSD < 33.3 mm and > 48.3 mm in ninth gestational week was associated with a higher risk of pregnancy loss. These models and thresholds may help physicians and patients make more informed decisions together. Further studies are needed to confirm the results.
建立特定孕周复发性流产女性妊娠结局预测模型，可为患者和医生提供更精准的信息，最终节省与不必要复诊相关的时间和成本。因此，我们旨在为 RPL 患者建立预测早期妊娠丢失的模型。我们使用妊娠早期的超声指标，结合人口统计学特征和常用的血清标志物。各周的独立危险因素如下：第 5 周的年龄和 P；第 6 周的年龄、mGSD 和 CRL；第 7 周的年龄、hCG 和 CRL；第 8 周的 CRL；第 9 周的 mGSD 和 CRL。相应的 AUC 分别为 0.671、0.796、0.872、0.871、0.813。年龄与早期妊娠丢失呈线性关系。hCG < 69,636.6 mIU/ml 与第 7 孕周妊娠丢失风险增加相关。mGSD 在第 6 周校正年龄、BMI 和既往妊娠丢失后<18.3mm，与早期妊娠丢失风险增加相关。第 6、7、8 和 9 周时 CRL 测量值（小于 2.4mm、9.9mm、16.9mm 和 18.6mm）较小，与早期妊娠丢失风险增加密切相关。此外，第 9 孕周的 mGSD < 33.3mm 和 > 48.3mm 与妊娠丢失风险增加相关。这些模型和阈值可能有助于医生和患者共同做出更明智的决策。需要进一步的研究来证实这些结果。
