路易体相关病理学的积累始于中年：坦佩雷猝死研究。

Accumulation of Lewy-Related Pathology Starts in Middle Age: The Tampere Sudden Death Study.

机构信息

Department of Pathology, University of Helsinki, Helsinki, Finland.

Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

出版信息

Ann Neurol. 2024 May;95(5):843-848. doi: 10.1002/ana.26912. Epub 2024 Mar 19.

DOI:10.1002/ana.26912

PMID:38501694

Abstract

When effective treatments against neurodegenerative diseases become a reality, it will be important to know the age these pathologies begin to develop. We investigated alpha-synuclein pathology in brain tissue of the Tampere Sudden Death Study-unselected forensic autopsies on individuals living outside hospital institutions in Finland. Of 562 (16-95 years) participants, 42 were positive for Lewy-related pathology (LRP). The youngest LRP case was aged 54 years, and the frequency of LRP in individuals aged ≥50 years was 9%. This forensic autopsy study indicates LRP starts already in middle age and is more common than expected in the ≥50 years-of-age non-hospitalized population. ANN NEUROL 2024;95:843-848.

摘要

当针对神经退行性疾病的有效治疗成为现实时，了解这些疾病开始发展的年龄将非常重要。我们研究了芬兰非住院医疗机构中突然死亡研究中未经选择的法医尸检中脑组织中的α-突触核蛋白病理学。在 562 名（16-95 岁）参与者中，42 名存在与路易体相关的病理学（LRP）。最年轻的 LRP 病例为 54 岁，≥50 岁人群中 LRP 的频率为 9%。这项法医尸检研究表明，LRP 已经开始在中年出现，并且在≥50 岁的非住院人群中比预期更为常见。ANN NEUROL 2024；95:843-848。