基于万塔85岁及以上人群研究中的杏仁核α-突触核蛋白病理学
Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study.
作者信息
Raunio Anna, Myllykangas Liisa, Kero Mia, Polvikoski Tuomo, Paetau Anders, Oinas Minna
机构信息
Department of Pathology, University of Helsinkiand Helsinki University Hospital, Helsinki, Finland.
Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK.
出版信息
J Alzheimers Dis. 2017;58(3):669-674. doi: 10.3233/JAD-170104.
Abstract
We investigated the frequency of Lewy-related pathology (LRP) in the amygdala among the population-based Vantaa 85+ study. Data of amygdala samples (N = 304) immunostained with two α-synuclein antibodies (clone 42 and clone 5G4) was compared with the previously analyzed LRP and AD pathologies from other brain regions. The amygdala LRP was present in one third (33%) of subjects. Only 5% of pure AD subjects, but 85% of pure DLB subjects had LRP in the amygdala. The amygdala LRP was associated with dementia; however, the association was dependent on LRP on other brain regions, and thus was not an independent risk factor. The amygdala-predominant category was a rare (4%) and heterogeneous group.
摘要
在基于人群的万塔85岁及以上研究中，我们调查了杏仁核中路易体相关病理（LRP）的发生率。将用两种α-突触核蛋白抗体（克隆42和克隆5G4）免疫染色的杏仁核样本（N = 304）的数据与先前分析的其他脑区的LRP和AD病理进行了比较。三分之一（33%）的受试者存在杏仁核LRP。纯AD受试者中只有5%有杏仁核LRP，但纯DLB受试者中有85%有杏仁核LRP。杏仁核LRP与痴呆相关；然而，这种关联依赖于其他脑区的LRP，因此不是一个独立的危险因素。以杏仁核为主的类别是一个罕见（4%）且异质性的组。
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