Dow University of Health Sciences, Karachi, Pakistan.
Jinnah Sindh Medical University, Karachi, Pakistan.
Neurosurg Rev. 2024 Mar 19;47(1):122. doi: 10.1007/s10143-024-02361-9.
This letter to the editor critiques a recent study evaluating the role of biologically effective dose (BED) in stereotactic radiosurgical thalamotomy for essential tremor (ET). The study, conducted retrospectively on 78 ET patients, demonstrates a significant correlation between BED and tremor improvement post-SRS. Moreover, the study suggests adjusting the prescribed dose rather than changing cobalt-60 sources to maintain treatment efficacy while minimizing toxicity. This suggestion aligns with previous research indicating an annual decrease in BED due to cobalt-60 decay. The letter emphasizes the importance of considering BED and cobalt-60 decay in optimizing treatment outcomes for ET patients undergoing stereotactic radiosurgery. Further research is recommended to explore innovative techniques for dose modulation in response to cobalt-60 decay and validate findings in larger cohorts.
这封给编辑的信批评了最近一项评估立体定向放射外科丘脑切开术治疗原发性震颤（ET）中生物有效剂量（BED）作用的研究。该研究回顾性地对 78 例 ET 患者进行了研究，表明 BED 与 SRS 后震颤改善之间存在显著相关性。此外，该研究还建议调整规定剂量，而不是改变钴-60 源，以在最小化毒性的同时保持治疗效果。这一建议与之前的研究一致，该研究表明由于钴-60 的衰减，BED 每年都会减少。这封信强调了在对接受立体定向放射外科治疗的 ET 患者进行治疗时，考虑 BED 和钴-60 衰减以优化治疗结果的重要性。建议进一步研究探索针对钴-60 衰减的剂量调制创新技术，并在更大的队列中验证研究结果。
