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Antagonistic effects of the cytotoxic molecules granzyme B and TRAIL in the immunopathogenesis of sclerosing cholangitis.细胞毒性分子 granzyme B 和 TRAIL 在硬化性胆管炎免疫发病机制中的拮抗作用。
Hepatology. 2024 Oct 1;80(4):844-858. doi: 10.1097/HEP.0000000000000830. Epub 2024 Mar 5.
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Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice.在小鼠中，向胆道滴注一种SMAC模拟物会诱导依赖TRAIL的急性硬化性胆管炎样损伤。
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Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis.肿瘤坏死因子相关凋亡诱导配体（TRAIL）诱导的凋亡不需要受体介导的内吞作用。
J Biol Chem. 2007 Apr 27;282(17):12831-41. doi: 10.1074/jbc.M700438200. Epub 2007 Feb 27.
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The enhanced expression of death receptor 5 (DR5) mediated by HBV X protein through NF-kappaB pathway is associated with cell apoptosis induced by (TNF-α related apoptosis inducing ligand) TRAIL in hepatoma cells.由乙肝病毒X蛋白通过核因子κB途径介导的死亡受体5（DR5）表达增强，与肿瘤坏死因子-α相关凋亡诱导配体（TRAIL）诱导的肝癌细胞凋亡有关。
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Tumor necrosis factor-related apoptosis-inducing ligand on NK cells protects from hepatic ischemia-reperfusion injury.NK 细胞表面的肿瘤坏死因子相关凋亡诱导配体可防止肝脏缺血再灌注损伤。
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Vismodegib suppresses TRAIL-mediated liver injury in a mouse model of nonalcoholic steatohepatitis.维莫德吉抑制 TRAIL 介导的非酒精性脂肪性肝炎小鼠模型中的肝损伤。
PLoS One. 2013 Jul 22;8(7):e70599. doi: 10.1371/journal.pone.0070599. Print 2013.

本文引用的文献

1
Antagonistic effects of the cytotoxic molecules granzyme B and TRAIL in the immunopathogenesis of sclerosing cholangitis.细胞毒性分子 granzyme B 和 TRAIL 在硬化性胆管炎免疫发病机制中的拮抗作用。
Hepatology. 2024 Oct 1;80(4):844-858. doi: 10.1097/HEP.0000000000000830. Epub 2024 Mar 5.
2
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) deletion in myeloid cells augments cholestatic liver injury.髓系细胞中肿瘤坏死因子相关凋亡诱导配体（TRAIL）缺失会加剧胆汁淤积性肝损伤。
Sci Rep. 2024 Jan 25;14(1):2145. doi: 10.1038/s41598-024-52710-3.
3
Immunobiology of the biliary tract system.胆道系统的免疫生物学。
J Hepatol. 2022 Dec;77(6):1657-1669. doi: 10.1016/j.jhep.2022.08.018. Epub 2022 Sep 16.
4
A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells.原发性硬化性胆管炎的胆汁免疫景观图谱揭示了中性粒细胞和组织驻留T细胞的主导网络。
Sci Transl Med. 2021 Jun 23;13(599). doi: 10.1126/scitranslmed.abb3107.
5
Single-cell atlas of hepatic T cells reveals expansion of liver-resident naive-like CD4 T cells in primary sclerosing cholangitis.单细胞肝脏 T 细胞图谱揭示原发性硬化性胆管炎中肝固有初始样 CD4 T 细胞的扩增。
J Hepatol. 2021 Aug;75(2):414-423. doi: 10.1016/j.jhep.2021.03.016. Epub 2021 Mar 24.
6
Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor Deficiency Promotes the Ductular Reaction, Macrophage Accumulation, and Hepatic Fibrosis in the Abcb4 Mouse.肿瘤坏死因子相关凋亡诱导配体受体缺陷促进 Abcb4 小鼠的胆小管反应、巨噬细胞积聚和肝纤维化。
Am J Pathol. 2020 Jun;190(6):1284-1297. doi: 10.1016/j.ajpath.2020.02.013. Epub 2020 Mar 30.
7
Interferon-γ-dependent immune responses contribute to the pathogenesis of sclerosing cholangitis in mice.干扰素-γ 依赖性免疫应答有助于小鼠硬化性胆管炎的发病机制。
J Hepatol. 2019 Oct;71(4):773-782. doi: 10.1016/j.jhep.2019.05.023. Epub 2019 Jun 5.
8
Primary Sclerosing Cholangitis.原发性硬化性胆管炎
N Engl J Med. 2016 Sep 22;375(12):1161-70. doi: 10.1056/NEJMra1506330.
9
Perforin and granzymes work in synergy to mediate cholangiocyte injury in experimental biliary atresia.穿孔素和颗粒酶协同作用介导实验性胆道闭锁中的胆管细胞损伤。
J Hepatol. 2014 Feb;60(2):370-6. doi: 10.1016/j.jhep.2013.09.021. Epub 2013 Oct 2.
10
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.对免疫相关疾病区域进行密集基因分型，确定原发性硬化性胆管炎的 9 个新风险位点。
Nat Genet. 2013 Jun;45(6):670-5. doi: 10.1038/ng.2616. Epub 2013 Apr 21.

Finding the TRAIL to escape granzyme B-mediated liver injury in PSC.

作者信息

Guicciardi Maria Eugenia, Jalan-Sakrikar Nidhi

机构信息

Division of Gastroenterology and Hepatology, Center for Cell Signaling in Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

出版信息

Hepatology. 2024 Oct 1;80(4):770-772. doi: 10.1097/HEP.0000000000000859. Epub 2024 Mar 19.

DOI:10.1097/HEP.0000000000000859
PMID:38502805
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11758847/
Abstract
摘要