College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu 610041, China.
Biomacromolecules. 2024 Apr 8;25(4):2438-2448. doi: 10.1021/acs.biomac.3c01385. Epub 2024 Mar 19.
The treatment of infected wounds faces substantial challenges due to the high incidence and serious infection-related complications. Natural-based hydrogel dressings with favorable antibacterial properties and strong applicability are urgently needed. Herein, we developed a composite hydrogel by constructing multiple networks and loading ciprofloxacin for infected wound healing. The hydrogel was synthesized via a Schiff base reaction between carboxymethyl chitosan and oxidized sodium alginate, followed by the polymerization of the acrylamide monomer. The resultant hydrogel dressing possessed a good self-healing ability, considerable compression strength, and reliable compression fatigue resistance. In vitro assessment showed that the composite hydrogel effectively eliminated bacteria and exhibited an excellent biocompatibility. In a model of -infected full-thickness wounds, wound healing was significantly accelerated without scars through the composite hydrogel by reducing wound inflammation. Overall, this study opens up a new way for developing multifunctional hydrogel wound dressings to treat wound infections.
由于感染发生率高和严重的感染相关并发症，感染伤口的治疗面临巨大挑战。急需具有良好抗菌性能和强适用性的天然基水凝胶敷料。本文通过构建多重网络并负载环丙沙星，开发了一种用于感染性伤口愈合的复合水凝胶。该水凝胶通过羧甲基壳聚糖和氧化的海藻酸钠之间的席夫碱反应合成，然后丙烯酰胺单体聚合。所得水凝胶敷料具有良好的自修复能力、相当大的压缩强度和可靠的压缩疲劳阻力。体外评估表明，复合水凝胶通过减少伤口炎症，有效消除细菌并表现出优异的生物相容性。在感染的全厚创面模型中，通过复合水凝胶显著加速了创面愈合，且无瘢痕形成。总的来说，这项研究为开发治疗伤口感染的多功能水凝胶伤口敷料开辟了新途径。
