Wang Chunxiao, Zhang Xinyu, Fan Yinuo, Yu Shuhan, Liu Man, Feng Linhan, Sun Qisen, Pan Panpan
Marine College, Shandong University, Weihai 264209, China.
National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai 200025, China.
Polymers (Basel). 2024 Jul 6;16(13):1937. doi: 10.3390/polym16131937.
Over millions of years of evolution, nature has developed a myriad of unique features that have inspired the design of adhesives for wound healing. Bionic hydrogel adhesives, capable of adapting to the dynamic movements of tissues, possess superior biocompatibility and effectively promote the healing of both external and internal wounds. This paper provides a systematic review of the design and principles of these adhesives, focusing on the treatment of skin wounds, and explores the feasibility of incorporating nature-inspired properties into their design. The adhesion mechanisms of bionic adhesives are analyzed from both chemical and physical perspectives. Materials from natural and synthetic polymers commonly used as adhesives are detailed regarding their biocompatibility and degradability. The multifunctional design elements of hydrogel adhesives for skin trauma treatment, such as self-healing, drug release, responsive design, and optimization of mechanical and physical properties, are further explored. The aim is to overcome the limitations of conventional treatments and offer a safer, more effective solution for the application of bionic wound dressings.
在数百万年的进化过程中，大自然发展出了无数独特的特性，这些特性为伤口愈合用粘合剂的设计提供了灵感。能够适应组织动态运动的仿生水凝胶粘合剂具有卓越的生物相容性，能有效促进体表和体内伤口的愈合。本文对这些粘合剂的设计和原理进行了系统综述，重点关注皮肤伤口的治疗，并探讨了将受自然启发的特性融入其设计的可行性。从化学和物理角度分析了仿生粘合剂的粘附机制。详细介绍了常用作粘合剂的天然和合成聚合物材料的生物相容性和可降解性。进一步探讨了用于皮肤创伤治疗的水凝胶粘合剂的多功能设计元素，如自愈性、药物释放、响应性设计以及力学和物理性能的优化。目的是克服传统治疗方法的局限性，为仿生伤口敷料的应用提供更安全、更有效的解决方案。
