Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Iran; Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Department of Pediatric Nursing, School of Nursing and Midwifery; Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
J Trace Elem Med Biol. 2024 Jul;84:127423. doi: 10.1016/j.jtemb.2024.127423. Epub 2024 Mar 4.
Since little is known about the comparison of the biotoxic effects of heavy metals exposure on biochemical and hematological parameters in miners and non-miners, the current study aimed to compare the effects of arsenic (As), lead (Pb), and copper (Cu) in both groups. Demographic information and blood samples were collected from all participants and measures of As, Pb and Cu were obtained using Atomic Absorption Spectrophotometry. As and Pb mean concentrations in miners and Cu concentration were greater in non-miners. Miners also showed significantly higher level of RBC, HBG and HCT. In the adjusted model, cholesterol showed a positively association with Pb and Cu levels. Triglycerides, GGT, ALP, WBC and PLT positively and HDL-cholesterol negatively were associated with Cu. Creatinine was negatively associated with group variable. In conclusion, miners' high blood heavy metals concentrations can impact biochemical and hematological indices. These observations make monitoring of heavy metals necessary in miners.
由于人们对矿工和非矿工暴露于重金属对生化和血液参数的生物毒性影响知之甚少，因此本研究旨在比较砷（As）、铅（Pb）和铜（Cu）在这两组人群中的影响。从所有参与者中收集人口统计学信息和血液样本，并使用原子吸收分光光度法测量 As、Pb 和 Cu 的含量。矿工的 As 和 Pb 平均浓度以及非矿工的 Cu 浓度更高。矿工的 RBC、HBG 和 HCT 水平也明显更高。在调整后的模型中，胆固醇与 Pb 和 Cu 水平呈正相关。甘油三酯、GGT、ALP、WBC 和 PLT 与 Cu 呈正相关，而 HDL-胆固醇与 Cu 呈负相关。肌酐与组变量呈负相关。总之，矿工血液中重金属浓度高会影响生化和血液参数。这些观察结果表明，有必要对矿工进行重金属监测。
