He Yan, Liao Ke, Peng Hua, Zou Xiangman, Guo Zifen
Institute of Pharmacy and Pharmacology, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Hunan Institute of Traffic Engineering, Hengyang, Hunan, 421019, China.
Comb Chem High Throughput Screen. 2025;28(1):3-11. doi: 10.2174/0113862073299444240308145725.
Endometrial carcinoma (EC) is a common malignancy worldwide. Existing evidence has revealed that EC could be associated with abnormal gene expression. Meantime, evidence supports that miRNAs act as critical regulators in gene expression through the binding to the 3'- untranslated region (3'-UTR). Accordingly, this review concludes some recent studies focusing on miRNAs that influence EC, aiming at understanding the association between miRNAs and EC more clearly and providing a reference for further studies on miRNA-related drugs treating EC.
子宫内膜癌（EC）是全球范围内常见的恶性肿瘤。现有证据表明，EC可能与基因表达异常有关。同时，有证据支持微小RNA（miRNA）通过与3'非翻译区（3'-UTR）结合，在基因表达中起关键调节作用。因此，本综述总结了一些近期关于影响EC的miRNA的研究，旨在更清楚地了解miRNA与EC之间的关联，并为进一步研究治疗EC的miRNA相关药物提供参考。
