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转移性骨病患者的髋关节置换术结果

Hip Arthroplasty Outcomes in Patients with Metastatic Bone Disease.

作者信息

Tepper Sarah C, Lee Linus, Kasson Lucas B, Herbst Leyla R, Vijayakumar Gayathri, Colman Matthew W, Gitelis Steven, Blank Alan T

机构信息

Rush University Medical Center.

Midwest Orthopedics at Rush University Medical Center.

出版信息

Orthop Rev (Pavia). 2024 Mar 17;16:94568. doi: 10.52965/001c.94568. eCollection 2024.

Abstract

BACKGROUND/OBJECTIVE: The hip is a common location for metastatic bone disease (MBD) and surgical intervention is often indicated to relieve pain and improve function. MBD of the hip is usually treated with hemiarthroplasty or with total hip arthroplasty if there are acetabular lesions. As treatment for metastatic disease evolves and patients may expect to live longer after diagnosis, further evaluation of the complications and functional outcomes associated with hip arthroplasty for MBD are necessary.

METHODS

This was a retrospective review of patients who underwent hip arthroplasty for MBD at a single institution between 2007 and 2021. Outcomes included rates of reoperation, complications, and overall survival.

RESULTS

Ninety-three cases in 91 patients were included. Total hip arthroplasty (THA) was performed in 52 cases (55.9%), hemiarthroplasty in 15 (16.1%), and complex arthroplasty, including proximal femur replacement or THA with complex acetabular reconstruction, was performed in 26 (28%). There were 11 reoperations in five patients and six dislocations. Median survival was 10.4 months and one-year overall survival was 53.3%. There was a significant increase in the proportion of patients who were able to ambulate independently (35.2% vs 17.6%; p=0.02) and a significant decrease in patients confined to a wheelchair (18.7% vs 3.3%; p=0.045) after surgery.

CONCLUSIONS

Hip arthroplasty for MBD leads to relatively low rates of complications and reoperations in this population known to have high postoperative morbidity and mortality. Hip arthroplasty provides the majority of MBD patients with a durable reconstruction that exceeds their lifespan and enables them to return to an acceptable level of function.

摘要

背景/目的:髋关节是转移性骨病(MBD)的常见发病部位,通常需要进行手术干预以缓解疼痛并改善功能。如果存在髋臼病变,髋关节MBD通常采用半髋关节置换术或全髋关节置换术治疗。随着转移性疾病治疗方法的不断发展,患者在确诊后可能期望活得更长,因此有必要进一步评估与髋关节置换术治疗MBD相关的并发症和功能结局。

方法

这是一项对2007年至2021年期间在单一机构接受髋关节置换术治疗MBD的患者进行的回顾性研究。结局指标包括再次手术率、并发症发生率和总生存率。

结果

纳入91例患者的93例病例。52例(55.9%)进行了全髋关节置换术(THA),15例(16.1%)进行了半髋关节置换术,26例(28%)进行了复杂关节置换术,包括股骨近端置换或带复杂髋臼重建的THA。5例患者进行了11次再次手术,发生6例脱位。中位生存期为10.4个月,1年总生存率为53.3%。术后能够独立行走的患者比例显著增加(35.2%对17.6%;p=0.02),而局限于轮椅的患者比例显著下降(18.7%对3.3%;p=0.045)。

结论

在已知术后发病率和死亡率较高的人群中,髋关节置换术治疗MBD导致的并发症和再次手术率相对较低。髋关节置换术为大多数MBD患者提供了一种持久的重建方式,其效果超过患者的预期寿命,并使他们能够恢复到可接受的功能水平。

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