Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
J Arthroplasty. 2019 Nov;34(11):2698-2703. doi: 10.1016/j.arth.2019.06.019. Epub 2019 Jun 18.
As oncology patients have increasing life expectancies, total hip arthroplasty (THA) may become an important treatment option for pathologic proximal femur fractures (PPFFs). Although THA and hemiarthroplasty (HA) have been compared for native hip fracture treatment, no data on short-term morbidity and mortality are available in the pathologic setting. The purpose of this study is to compare short-term morbidity and mortality of HA vs THA for PPFFs.
The National Surgical Quality Improvement Program database was queried from 2007 to 2017 for patients with PPFFs treated with HA or THA. Propensity-adjusted logistic regressions were implemented to compare 30-day morbidity and mortality between procedures. Backwards stepwise regression was then used to determine independent predictors of treatment with HA compared to THA.
In adjusted analysis, THA was associated with longer operative times (120.3 ± 5.6 vs 98.7 ± 4.9 minutes, P < .001); however, there were no differences between THA and HA with regard to 30-day rates of major complications (P = .3), minor complications (P = .77), reoperations (P = .99), readmissions (P = .35), or deaths (P = .63). Older age (P < .001), dependent functional status (P = .02), and the presence of disseminated cancer (P = .049) were predictive of undergoing HA compared to THA.
As patients with metastatic cancer continue to live longer with their disease, the durability of surgical reconstruction to treat PPFFs is becoming increasingly important. This study demonstrated no significant differences in 30-day complications between PPFF patients treated with THA or HA after controlling for underlying confounders. These results suggest that THA can be utilized to treat certain patients with PPFFs, and future work is warranted to examine long-term functional outcomes.
随着肿瘤患者的预期寿命不断延长,全髋关节置换术(THA)可能成为病理性股骨近端骨折(PPFF)的重要治疗选择。虽然 THA 和半髋关节置换术(HA)已被用于比较原发性髋关节骨折的治疗,但在病理性骨折中尚无短期发病率和死亡率的数据。本研究旨在比较 HA 与 THA 治疗 PPFF 的短期发病率和死亡率。
从 2007 年至 2017 年,国家手术质量改进计划数据库中检索到接受 HA 或 THA 治疗的 PPFF 患者。实施倾向调整逻辑回归以比较两种手术方法 30 天内的发病率和死亡率。然后使用向后逐步回归确定与 HA 治疗相比,THA 治疗的独立预测因素。
在调整分析中,THA 与较长的手术时间相关(120.3±5.6 分钟 vs 98.7±4.9 分钟,P<.001);然而,THA 和 HA 在 30 天内主要并发症发生率(P=0.3)、次要并发症发生率(P=0.77)、再次手术率(P=0.99)、再入院率(P=0.35)或死亡率(P=0.63)方面无差异。年龄较大(P<.001)、依赖功能状态(P=0.02)和存在转移性癌症(P=0.049)是接受 HA 治疗而不是 THA 治疗的预测因素。
随着转移性癌症患者的寿命不断延长,治疗 PPFF 的手术重建的耐久性变得越来越重要。在控制潜在混杂因素后,本研究表明,接受 THA 或 HA 治疗的 PPFF 患者在 30 天内的并发症无显著差异。这些结果表明,THA 可用于治疗某些 PPFF 患者,需要进一步研究以检查长期功能结果。