Department of Periodontology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, India.
J Long Term Eff Med Implants. 2024;34(3):9-12. doi: 10.1615/JLongTermEffMedImplants.2023047580.
Peri-implant disease pathogenesis is similar to periodontal disease pathogenesis resulting in production of pro-inflammatory mediators. These mediators alter the redox balance leading to decrease in antioxidants, among which catalase is one of the enzymatic antioxidants. The aim of the study was to compare the levels of catalase in peri-implant health and disease. The present observational study was carried out from June 2022 to December 2022 in the Department of Implantology, Saveetha Dental College and Hospitals, Chennai, India. A total of 60 patients with peri-implant health (Group 1; n = 20), peri-implant mucositis (Group 2; n = 20) and peri-implantitis (Group 3; n = 20) were enrolled. Unstimulated salivary samples were collected and subjected to ELISA for catalase analysis. Catalase levels were then compared between the groups using ANOVA. The mean catalase level in peri-implant health, peri-implant mucositis, peri-implanti-tis were 25.07 ± 0.44 U/mL, 18.5 6 ± 0.65 U/mL, and 11.25 ± 0.76 U/mL respectively. The difference between the three groups were statistically significant (P < 0.05). Catalase level decreases with severity of peri-implant diseases. Therefore, catalase can be used as a diagnostic marker for peri-implant diseases.
种植体周围疾病的发病机制与牙周病的发病机制相似，导致促炎介质的产生。这些介质改变了氧化还原平衡，导致抗氧化剂减少，其中过氧化氢酶是一种酶抗氧化剂。本研究旨在比较种植体健康和疾病状态下过氧化氢酶的水平。本观察性研究于 2022 年 6 月至 2022 年 12 月在印度钦奈的 Saveetha 牙科医学院和医院的种植科进行。共纳入 60 名种植体健康患者（第 1 组；n = 20）、种植体周围黏膜炎患者（第 2 组；n = 20）和种植体周围炎患者（第 3 组；n = 20）。采集未刺激的唾液样本，通过 ELISA 分析过氧化氢酶。然后使用方差分析比较组间的过氧化氢酶水平。种植体健康、种植体周围黏膜炎和种植体周围炎患者的平均过氧化氢酶水平分别为 25.07 ± 0.44 U/mL、18.56 ± 0.65 U/mL 和 11.25 ± 0.76 U/mL。三组间的差异具有统计学意义（P < 0.05）。随着种植体周围疾病的严重程度，过氧化氢酶水平降低。因此，过氧化氢酶可以作为种植体周围疾病的诊断标志物。
