Mannhalter C, Deutsch E, Kopsa H
Thromb Res. 1985 Aug 15;39(4):475-84. doi: 10.1016/0049-3848(85)90171-9.
Factor XII, prekallikrein (PK) and high molecular weight kininogen (HMWK) clotting activities and antigen concentrations in kidney disease patients were studied. Chronic hemodialysis led to a reduction of F XII, PK and HMWK clotting activities. F XII and PK antigen levels were also low. In contrast, the HMWK antigen was normal with respect to concentration as well as electrophoretic migration behaviour on 2 D-immunelectrophoresis. In kidney transplant recipients more than three month after the transplantation, we found an increased of F XII and PK clotting activities, which appeared to depend on the time elapsed since the operation. However, the antigen levels remained normal. The group of chronic kidney disease patients not requiring hemodialysis exhibited normal mean values of all three clotting activities as well as normal F XII and HMWK antigen levels. The PK antigen was reduced. However, a separate evaluation of F XII clotting activities (F XII:C) in patients with glomerular nephritis showed elevated F XII:C which correlated with the BUN values. During acute processes of the kidney disease we observed very high PK clotting activities, which normalized with stabilization of the patients. Our results show that the contact phase coagulation factors behave abnormally in certain kidney disease patients.
我们研究了肾病患者中凝血因子 XII、前激肽释放酶（PK）和高分子量激肽原（HMWK）的凝血活性及抗原浓度。慢性血液透析导致凝血因子 XII、PK 和 HMWK 的凝血活性降低。凝血因子 XII 和 PK 的抗原水平也较低。相比之下，HMWK 的抗原在浓度以及二维免疫电泳上的电泳迁移行为方面均正常。在肾移植受者术后三个月以上，我们发现凝血因子 XII 和 PK 的凝血活性增加，这似乎取决于手术之后经过的时间。然而，抗原水平仍保持正常。不需要进行血液透析的慢性肾病患者组，所有三项凝血活性的平均值以及凝血因子 XII 和 HMWK 的抗原水平均正常。PK 的抗原降低。然而，对肾小球肾炎患者的凝血因子 XII 凝血活性（F XII:C）进行单独评估时发现，F XII:C 升高，且与血尿素氮值相关。在肾病的急性病程中，我们观察到 PK 的凝血活性非常高，随着患者病情稳定而恢复正常。我们 的结果表明，接触相凝血因子在某些肾病患者中表现异常。
