原发性护理人群中降压药与帕金森病的关联，按潜在诊断匹配。
Association of antihypertensives and Parkinson's disease in a primary care population matched for underlying diagnosis.
机构信息
Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
University Clinic, Philipps-University, Marburg, Germany.
出版信息
PLoS One. 2024 Mar 20;19(3):e0299985. doi: 10.1371/journal.pone.0299985. eCollection 2024.
PURPOSE
To examine the association of several antihypertensive medication classes with incidence of Parkinson's disease (PD), taking into account possible underlying conditions.
METHODS
In a case-control study based on a large primary care database and including 21,981 PD cases and 21,981 non-PD controls matched for age, sex, and possible treatment indications associations with different antihypertensive medication groups, including diuretics, betablockers, calcium channel blockers, angiotensin-converting enzyme inhibitors and angiotensin-II receptor-blockers and PD were examined.
RESULTS
Antihypertensive medications overall were associated with a lower risk of subsequent diagnosis of PD (OR: 0.94, 95% CI 0.90-0.97), with the negative association most significant for medications acting on the renin-angiotensin-aldosterone system. A positive association with diagnosis of PD was only seen for betablockers and restricted to those with relatively young age and not in those with longer treatment duration.
CONCLUSION
When taking into account underlying diagnoses, antihypertensive medications overall were associated with a reduced incidence of PD.
目的
探讨几种降压药物类别与帕金森病（PD）发病的关联，同时考虑到潜在的基础疾病。
方法
基于大型初级保健数据库的病例对照研究，共纳入 21981 例 PD 病例和 21981 例年龄、性别和可能的治疗指征相匹配的非 PD 对照者，分析了不同降压药物类别（利尿剂、β受体阻滞剂、钙通道阻滞剂、血管紧张素转换酶抑制剂和血管紧张素 II 受体阻滞剂）与 PD 的关联。
结果
降压药物总体上与 PD 后续诊断风险降低相关（OR：0.94，95%CI 0.90-0.97），与肾素-血管紧张素-醛固酮系统作用的药物的负相关最为显著。仅β受体阻滞剂与 PD 的诊断呈正相关，且仅限于年龄相对较小且治疗时间较短的患者，而不是治疗时间较长的患者。
结论
考虑到潜在的诊断，降压药物总体上与 PD 发病率降低相关。
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